Advances in erlotinib delivery systems: Addressing challenges and exploring opportunities in EGFR-targeted cancer therapies

M Pourmadadi, V Mohammadzadeh… - Inorganic Chemistry …, 2024 - Elsevier
… the difficulty posed by erlotinib resistance. Delivery systems … bioavailability and solubility
of erlotinib, thereby potentially … the precise administration of erlotinib to particular malignant …

QbD assisted development of inhalable spray-dried erlotinib procubosomal system for the effective management of non-small cell lung cancer

A Singh, V Rana - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
… The four experimental groups established for comparative studies were as follows: Group
I rats received a 10 mg/kg dose of pure ERL via oral delivery, Group II rats received the same …

[HTML][HTML] Effectiveness and safety of the bevacizumab and erlotinib combination versus erlotinib alone in EGFR mutant metastatic non-small-cell lung cancer …

R Motta-Guerrero, A Leon Garrido-Lecca… - Frontiers in …, 2024 - frontiersin.org
… and erlotinib, we searched databases including clinical trial randomized studies and reviews
… In conclusion, the study shows that the bevacizumab–erlotinib combination significantly …

[HTML][HTML] Oral squamous cell carcinoma cells with acquired resistance to erlotinib are sensitive to anti-cancer effect of quercetin via pyruvate kinase M2 (PKM2)

CY Chan, SC Hong, CM Chang, YH Chen, PC Liao… - Cells, 2023 - mdpi.com
study, we aimed to unveil key intracellular molecules and adjuvant reagents to overcome
erlotinib … In conclusion, our data support the application of quercetin in anti-erlotinib-resistant …

Dual stimuli-responsive release of aptamer AS1411 decorated erlotinib loaded chitosan nanoparticles for non-small-cell lung carcinoma therapy

K Saravanakumar, A Sathiyaseelan… - Carbohydrate …, 2020 - Elsevier
… However, there is no report on application of aptamer-tagged Erlotinib loaded chitosan
nanoparticles. Hence the present study was to develop the DDS using the dual stimuli-…

… liquid chromatography method for erlotinib quantification in vitro: Application to study the effect of resveratrol on metabolism and cellular uptake of erlotinib

A Zayed, J Al Hroot, A Mayyas… - Fundamental & Clinical …, 2023 - Wiley Online Library
erlotinib formation: We studiedErlotinib and resveratrol concentration in our study were
chosen based on previous in vitro experiments that studied the effect of resveratrol on erlotinib

[HTML][HTML] Early [18] FDG PET/CT scan predicts tumor response in head and neck squamous cell cancer patients treated with erlotinib adjusted per smoking status

M Porosnicu, A O'Brien Cox, JD Waltonen… - Frontiers in …, 2022 - frontiersin.org
erlotinib among patients with HNSCC. For the first time, this study shows that an increased
erlotinib … 150 mg in non-smokers, with increased study-specific defined tumor response. The …

PEGylated erlotinib HCl injectable nanoformulation for improved bioavailability

H Bhargave, H Nijhawan, KS Yadav - AAPS PharmSciTech, 2023 - Springer
… An in vitro drug release study was performed in order to determine the release behavior of
the Erlotinib HCl from nanoparticles. For this study, freeze-dried nanoparticles of Erlotinib HCl …

An application of quality by design and analytical greenness assessment approach for the development of erlotinib stability indicating method

S Gundecha, M Patel, YC Mayur - Chromatographia, 2022 - Springer
Erlotinib (ERL) is a tyrosine kinase inhibitor associated with the epidermal growth factor
receptor (EGFR) containing susceptible functional groups such as quinazoline and amine ketone…

The lack of head-to-head randomised trials and the consequences for patients and national health service: The case of non-small cell lung cancer

R Lasala, A Romagnoli, F Santoleri, V Isgrò… - European Journal of …, 2024 - Springer
studies between the latest generation of drugs. Consequently, ambiguous areas exist due to
the lack of comparative studies … Additionally, the BEVERLY study aimed to study the erlotinib