Effect of the glycine transporter 1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset

I Frouni, S Belliveau, S Maddaford, SG Nuara… - European Journal of …, 2021 - Elsevier
… For each of these scales, the higher the score, the greater the … (AUC), after which one-way
analysis of variance (ANOVA) was … In C, data are presented as the median dyskinesia score

Effects of Coordinated Reset Deep Brain Stimulation of Subthalamic Nucleus on Parkinsonian Gait in the Non-Human Primate Model

K Nakajima - 2023 - digitalcommons.macalester.edu
… ) was presented along with a system to grade severity of PD … A study has reported that
dyskinesia and motor fluctuations … time required for data collection and analysis. In addition, the …

The mGluR2/3 orthosteric agonist LY-404,039 reduces dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset

W Kang, SG Nuara, D Bédard, I Frouni, C Kwan… - Naunyn-Schmiedeberg's …, 2023 - Springer
… (MPTP)-lesioned marmoset, a non-human primate with high predictive value of the success
analysis Time courses of parkinsonian disability, dyskinesia and PLB scores are presented

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

ME Caulfield, JA Stancati, K Steece-Collier - JoVE (Journal of Visualized …, 2021 - jove.com
… /AIMs scoring data, created using rating scales for assigning … protocol presented here is
specifically helpful for larger-scale … practices assessing LIDs in non-human primates (NHPs), the …

[图书][B] Towards therapies for Parkinson's Disease: treatment-related complications and animal models

C Kwan - 2022 - search.proquest.com
… -dyskinetic findings of ondansetron obtained in the rat to the parkinsonian non-human primate
the scope of the present review and has been excellently presented previously 41, 42. Age …

Combined mGlu2 orthosteric stimulation and positive allosteric modulation alleviates l-DOPA-induced psychosis-like behaviours and dyskinesia in the parkinsonian …

SG Nuara, A Hamadjida, C Kwan, D Bédard… - Journal of Neural …, 2020 - Springer
… of PD, the parkinsonian non-human primate, which has high … On each of these scales, the
higher the score, the greater the … parkinsonism, dyskinesia, and PLB scores are presented as …

Further characterisation of psychosis-like behaviours induced by L-DOPA in the MPTP-lesioned marmoset

C Kwan, SG Nuara, JC Gourdon, P Huot - … -Schmiedeberg's Archives of …, 2021 - Springer
… The parkinsonian disability rating scale is presented in Table … From the analysis of the
PLBs, we also observed that … conducted in this small primate. These additions to the existing …

The MPTP-lesioned marmoset model of Parkinson's disease: proposed efficacy thresholds that may potentially predict successful clinical trial results

F Beaudry, P Huot - Journal of Neural Transmission, 2020 - Springer
… To do so, we used the evidence-based medicine reviews … lesioned marmoset and identified
articles reporting the effects of drugs that … For the treatment of dyskinesia, we suggest that the …

Monoamine oxidase A inhibition with moclobemide enhances the anti-parkinsonian effect of L-DOPA in the MPTP-lesioned marmoset

A Hamadjida, SG Nuara, C Kwan, I Frouni… - Naunyn-Schmiedeberg's …, 2020 - Springer
dyskinesia score at any time point is 12. In A, data are presented as the median; in B, data are
presented … striatal dopamine in human and non-human primate (Riederer and Laux 2011), …

Serotonergic innervation of the striatum in a nonhuman primate model of Parkinson's disease

L Jiménez-Sánchez, J Blesa, NL Del Rey… - …, 2020 - Elsevier
… the serotonergic system in both PD and experimental parkinsonism in non-human primates,
we … Our stereological analysis did not find any changes in 5-HT+ axonal length density in the …