Levodopa-induced dyskinesia: A historical review of Parkinson's disease, dopamine, and modern advancements in research and treatment

CA Hansen, DR Miller, S Annarumma, CT Rusch… - Journal of …, 2022 - Springer
… 1817 by James Parkinson, patients presented with shaking palsy … non-human primate
PD models are outlined in two recent … ] led to the establishment of rating scales for l-DOPA-induced …

Molecular mechanisms and therapeutic strategies for levodopa-induced dyskinesia in Parkinson's disease: a perspective through preclinical and clinical evidence

R Bandopadhyay, N Mishra, R Rana, G Kaur… - Frontiers in …, 2022 - frontiersin.org
… treated primates having a higher degree of dopaminergic neuron degeneration show dyskinetic
… are used to measure the LID severity, which are similar to objective rating scales used in …

AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys

M Bourque, L Grégoire, W Patel, D Dickens… - Cells, 2022 - mdpi.com
… to the parkinsonian and dyskinetic scales developed at Laval … from the monkey experiments
were analyzed with an analysis of … The data presented in this study are available upon …

Additive effects of mGluR2 positive allosteric modulation, mGluR2 orthosteric stimulation and 5-HT2AR antagonism on dyskinesia and psychosis-like behaviours in …

SG Nuara, JC Gourdon, S Maddaford… - … Archives of Pharmacology, 2021 - Springer
… marmoset, a non-human primate with strong predictive … which we performed one-way
analysis of variance (ANOVA) … First, although we mentioned in the introduction that 5-HT 2A R …

Breathing new life into neurotoxic-based monkey models of Parkinson's disease to study the complex biological interplay between serotonin and dopamine

V Sgambato - Progress in Brain Research, 2021 - Elsevier
system without affecting the remaining DA neurons. The lesion of 5-HT fibers induced by
MDMA altered rigidity and prevented dyskinesia … In non-human primates (NHP), the use of the …

Evaluation of rhesus macaque models for cerebral palsy

Y Zhu, Y Xiong, J Zhang, H Tong, H Yang, Q Zhu, X Xu… - Brain Sciences, 2022 - mdpi.com
… Animal models, especially non-human primate models, have … to the left or right, dyskinesia,
and motor incoordination. … are usually assessed with clinical rating scales, such as gross and …

Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson's disease primate model

I Kaya, A Nilsson, D Luptáková, Y He… - npj Parkinson's …, 2023 - nature.com
… Hence, the presented findings improve our current … from a biobank of non-human primate
brains (Macaca mulatta) … to a comprehensive lipidomics analysis of coronal macaque brain …

Striatal Serotonin 4 Receptor is Increased in Experimental Parkinsonism and Dyskinesia

R Cirillo, S Duperrier, P Parekh, M Millot… - Journal of …, 2024 - content.iospress.com
… bank tissue from a rat and a non-human primate (NHP) model of PD. … For both species,
behavioral analysis and lesion … tests and scales (the rotational behavior and the scoring of axial, …

[HTML][HTML] Prophylactic action of ayahuasca in a non-human primate model of depressive-like behavior

MLP de Meiroz Grilo, GM Sousa… - Frontiers in Behavioral …, 2022 - frontiersin.org
… of resilience, in a non-human primate animal model, Callithrix … Furthermore, although studies
using non-human primates as … The evidence presented could stimulate a promising new …

Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson's disease and L-Dopa induced dyskinesia

L Malave, DR Zuelke, S Uribe-Cano, L Starikov… - Communications …, 2021 - nature.com
… in rodents and non-human primates have been developed … used in this study are presented
in Supplementary Fig. 1) and … is known to act across multiple time scales via both rapid G-…