… roles in the proliferation, differentiation, survival, migration, … the PKC inhibitor staurosporine
or the NF-κB inhibitor BAY 11-… phenotypes of pancreatic adenocarcinoma cells [251]. PKCζ …

… is a more selective PKC inhibitor compared to staurosporine, … and was found to inhibit
proliferation, induce differentiation, and … PKC412 or CGP 41251) is a staurosporine analog …

… , aiming to discover the selective inhibitors of PKC, mostly … as a PKC inhibitor analogous
to staurosporine, midostaurin … has been reported following kinase neutralization [251]. …

… selective small molecule modulators, we report in this dissertation the synthesis of a series
of novel carbamate derivatives of … derivatives is hydrophobicity- dependent and inhibition of …

… products and methods for finding new compounds which exhibit selective cytotoxicity. In
order to place this work in context, it is necessary to consider how the concept of selective …

… cancer cell lines against their inhibition through the Cancer … of selectivity and adverse effects
on a growing organism. … and influence oncogenesis and metastasis [251]. However, since …

… Tyrosine kinase is the most important protein kinases sub-… -b]pyrrolizine derivative, showed
selectivity towards the HCT116 … compound 5b as white crystals, mp 251–3 C, yield 59%, IRʋ …

… Compound 31 showed selective inhibition towards FPTase. … [51] inhibitors or DAHP 1 [52]
suggests that new derivatives of … structures of 40 and 41 (Figure 10) (40 GS = 6.3, 41 GS = 1.6), …

… the PKC inhibitor staurosporine or the NF-κB inhibitor BAY 11-… phenotypes of pancreatic
adenocarcinoma cells [251]. PKCζ … isoenzyme-selective modulation of protein kinase C. FASEB …

… selectivity of anticancer approaches has a low marginCitation 7 . So, it is a serious concern
to develop a new strategy of treating cancer that provides a high selectivity … Citation 41 and …