… for vaccine-induced protection against homologous challenge and … to elicit robust host
protection against cryptococcosis. … Several mutant strains, such as the strain overexpressing the …

… agent of cryptococcosis, a life-threatening invasive fungal … conferred complete host protection
to the WT strain even … To assess the longevity of the vaccine-induced host protection, we …

… The wild-type and mutant strains were heat killed at 99 ℃ for 5 min, and supernatants were
… against invasive cryptococcosis, and both Th1 and Th17 immune responses can be induced …

… Cryptococcus neoformans infections are significant causes of morbidity and mortality among
AIDS patients and the third most common invasive … chose to use heat-killed fungi to control …

… of heat-killed wild-type H99 would also offer host protection. … dose of heat-killed wild-type
H99 can also offer protection, we … to the vaccination effect induced by ZNF2 overexpression. If …

… We discovered that, when heat-killed (HK) cells … Many of the mutant strains have gene
mutations that affect the cell wall or cell membrane integrity, with the exception of the H99γ strain, …

… reported that Cryptococcus neoformans Δsgl1, a mutant strain that … conferred complete host
protection against the WT strain, we … fumigatus ΔsglA mutant in inducing host protection. To …

… The BC1076 cryptococcal strain causes persistent but … the heat-killed or the short-lived ZNF2
oe strain will provide … As live strains are more effective in providing host protection than heat-…

… Treatment options for invasive cryptococcal infection are … , despite the fact that it causes
substantial toxicity and that its … as hypermutator strains 30,31 , which contain mutations in core …

… mutant, the ability of live or heat-killed sglA mutant conidia to … To better define the mechanism
of host protection against IA, … , sgl1-null mutant-mediated protection against Cryptococcus …