… due to deposition of immunoglobulin light chains produced by a … All exons of TTR were
amplified using hybrid primers containing … We previously validated this approach against Sanger …

… gammopathy testing and amyloid typing by mass spectrometry of Congo-red … light chains
in plasma cell disorders. It can be used to identify patients at risk for light chain amyloidosis …

… to establish the type of amyloid fibril. A major advantage of … , mass spectrometry was able
to detect the amyloid protein in … been incorporated into well-validated prognostic models. The …

… in 9 patients, at diagnosis, for the purpose of amyloid typing in 6 (… Peptides were analyzed
on a QExactive mass spectrometer … in this study should be verified in a larger series collected …

… mass spectrometry and proteome profiling, have greatly improved the accuracy of amyloid
typing, … The concentrations of light chains in urine from amyloidosis patients may be very low. …

… “Gold standards” of amyloid typing: immuno-electron microscopy (… microdissection coupled
with tandem mass spectrometry (LCM-… If further validated across light chain amyloidogenic …

… protein involved (amyloid typing), using mass spectrometry of the biopsy sample. … A
modern primer on light chain amyloidosis in 592 patients with mass spectrometry-verified typing …

… We included all consecutive patients with AL amyloidosis who were diagnosed or treated
at … Amyloid typing was done by either mass spectrometry or immunohistochemistry. Two-sided …

… light chain (LC), then this is consistent with AL amyloidosis … mass spectrometry identified
both procalcitonin and calcitonin in the deposits. Serum calcitonin level measured in 1 patient …

… in caring for patients with AL amyloidosis, which are further … , and the exclusion of AL
amyloidosis patients from initial COVID-… Furthermore, there are no clinically validated tests to verify …