… to what pediatric neurologists now recognize as Rett syndrome. Citation3 … in mice showed
that transgenic expression of MeCP2_e2 was able to rescue of phenotypes of Mecp2 null mice…

… A mouse MECP2-null mutation causes neurological symptoms that mimic Rett syndrome. …
There are several other genes whose mutation causes features that overlap with Rett syndrome…

… symptom onset delivery of viral MeCP2 did not affect motor coordination in Mecp2 Null/+
mice… with our results showing that, in Mecp2 Null/+ mice, addition of the MECP2 transgene …

… important for brain function and is one of the most common causes in RTT (Rett syndrome) …
Rett syndrome symptoms can be regulated in mice, however there is no clear evidence on …

… Rett syndrome (RTT) is a rare neurological disorder caused by mutations in the X-linked
MECP2 gene and a major cause of … behavioural phenotype and brain mitochondria dysfunction …

… the brain of transgenic mice modeling the disease and in Rett … Since Rett syndrome is a
neurological disorder affecting both … in Mecp2 null cells and that are relevant for Rett syndrome. …

… expression in symptomatic RTT mice reverses clinical … -dependent phase of brain
development and that MeCP2 … may lead to deficits in the experience-dependent phase of brain …

… Despite this fact, the function of MeCP2 has been predominately studied in the nervous
system of Mecp2 null male mice as ablation of MeCP2 in all brain cells accounts for the most …

… Rett Syndrome (RTT) is a neurological disease in females … The disease mainly affects brain
development and the symptoms progress as … exhibited by Mecp2-null mice (Mecp2 −/Y ) [49]. …

… Our ability to distinguish differences between male Mecp2-null and female Mecp2 Het
mice is further compounded by phenotypic variability caused by skewed X-inactivation. X-…