Aversion hot spots in the dopamine system

JPH Verharen, Y Zhu, S Lammel - Current opinion in neurobiology, 2020 - Elsevier
… accumbens (NAc; mesolimbic pathway) or medial prefrontal … recordings (showing unitary
encoding of RPE). For example, it … to the excitatory responses to aversive stimuli [47], and (5) …

[HTML][HTML] Neural circuits provide insights into reward and aversion

W Chen - Frontiers in Neural Circuits, 2022 - frontiersin.org
… type encode motivational salience, being excited by both rewards and aversive stimuli, and
support the brain’s systems … to the mesolimbic system and negative feedback on the midbrain …

[HTML][HTML] Dopamine circuit mechanisms of addiction-like behaviors

CL Poisson, L Engel, BT Saunders - Frontiers in Neural Circuits, 2021 - frontiersin.org
… result in the delivery of noxious or otherwise aversive stimulus, such as footshock, or a bitter
encode threatening stimuli and threat avoidance, relative to positively valenced stimuli (…

A new look at the role of Mesoamygdaloid dopamine neurons in aversive conditioning

DFC Pinto, L Taniguchi, ZC Norville… - Journal of …, 2020 - Soc Neuroscience
… plasticity in the BLA as a fundamental neural mechanism underlying aversive learning. …
imply that dopamine may be driving aversive learning by an entirely different mechanism. …

[HTML][HTML] Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila

LY McCurdy, P Sareen, PA Davoudian… - Nature …, 2021 - nature.com
… the neural circuit mechanism through which Drosophila reward-encoding dopaminergic
Since a subset of VTA DANs have been found to respond to aversive stimuli such as electric …

[HTML][HTML] The central amygdala recruits mesocorticolimbic circuitry for pursuit of reward or pain

SM Warlow, EE Naffziger, KC Berridge - Nature communications, 2020 - nature.com
… indicates that an aversive stimulus can itself become a target of compulsive attraction, under
certain conditions that recruit mesocorticolimbic incentive circuitry. Maladaptive attraction …

[HTML][HTML] Mesolimbic dopamine release precedes actively sought aversive stimuli in mice

Y Yawata, Y Shikano, J Ogasawara, K Makino… - Nature …, 2023 - nature.com
… 12c, n = 8, one-sample bootstrap test), suggesting that AIC neuron ensembles encoded the
timings of nose pokes. We then examined the nose poke-relevant responses of AIC neurons …

Learned avoidance requires VTA KOR-mediated reductions in dopamine

MA Robble, ME Bozsik, DS Wheeler, RA Wheeler - Neuropharmacology, 2020 - Elsevier
… While the mesolimbic dopamine system is known to be … in this neural circuit and their activation
is aversive in both … on real time dopaminergic responses to aversive stimuli and learned …

[HTML][HTML] Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion

C Soares-Cunha, NAP de Vasconcelos… - Molecular …, 2020 - nature.com
neural circuits in detail. One of the key regions of the reward … receptor D2-expressing MSNs
(D2-MSNs) encode aversion. … , these also mediate/signal aversive stimuli, which is crucial to …

Illuminating subcortical GABAergic and glutamatergic circuits for reward and aversion

A Gordon-Fennell, GD Stuber - Neuropharmacology, 2021 - Elsevier
… Here, we review the past decade of optogenetic experiments to study the neural circuitry
of reinforcement and reward/aversion with a focus on the mesolimbic dopamine system and …