[HTML][HTML] Natural products in drug discovery: advances and opportunities
AG Atanasov, SB Zotchev, VM Dirsch… - … reviews Drug discovery, 2021 - nature.com
… natural product (NP)-based drug discovery shown in green boxes. The process begins with
extraction of NPs from organisms such as bacteria… high-throughput screening, crude extracts …
extraction of NPs from organisms such as bacteria… high-throughput screening, crude extracts …
The strategies and techniques of drug discovery from natural products
L Zhang, J Song, L Kong, T Yuan, W Li, W Zhang… - Pharmacology & …, 2020 - Elsevier
… The microorganisms and the endogenous active substances … Today, applying the
newly high throughput screening … HCS provides a new technique for studying drug effects, …
newly high throughput screening … HCS provides a new technique for studying drug effects, …
Bacterial natural product drug discovery for new antibiotics: strategies for tackling the problem of antibiotic resistance by efficient bioprospecting
YK Schneider - Antibiotics, 2021 - mdpi.com
… 4 ) of microbial metabolites became approved drugs and another … of a classical high-throughput
screening for antibiotic … where 67 high-throughput screening campaigns against different …
screening for antibiotic … where 67 high-throughput screening campaigns against different …
[HTML][HTML] The role of natural products as sources of therapeutic agents for innovative drug discovery
K Dzobo - Comprehensive pharmacology, 2022 - ncbi.nlm.nih.gov
… There are many challenges associated with high throughput screening assays during drug
discovery. Questions on who own the rights to plants found within certain regions and who …
discovery. Questions on who own the rights to plants found within certain regions and who …
High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases
… new drug targets and developing new treatments for NDDs. Moreover, we review the increasing
role of HTS in the drug discovery … new ways to treat ALS. Researchers at Benevolent Bio …
role of HTS in the drug discovery … new ways to treat ALS. Researchers at Benevolent Bio …
Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents
… , and bioassays with a high-throughput capacity to establish … of new approaches will further
improve the drug discovery … screening to fit in the timescale of high throughput screening […
improve the drug discovery … screening to fit in the timescale of high throughput screening […
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
… manipulating the quorum-sensing system 108 , phenotype-guided transposon mutagenesis
109 , correlating BGC distribution with metabolomic data 110 , developing a high-throughput …
109 , correlating BGC distribution with metabolomic data 110 , developing a high-throughput …
Unraveling plant natural chemical diversity for drug discovery purposes
E Lautié, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
… approach would be a way to guide some drug discovery projects. Another totally different
approach based on the use of high-throughput … Microorganisms, such as bacteria and yeasts, …
approach based on the use of high-throughput … Microorganisms, such as bacteria and yeasts, …
Natural products are a promising source for anthelmintic drug discovery
… since 2000 are derivatives of microbial products [90]. … extracts in their traditional medicine
may provide a more beneficial targeted approach compared to high-throughput screening of …
may provide a more beneficial targeted approach compared to high-throughput screening of …
[HTML][HTML] Acoustic droplet ejection facilitates cell-based high-throughput screenings using natural products
TA Mackenzie, JR Tormo, B Cautain, G Martínez… - SLAS technology, 2024 - Elsevier
… for the drug discovery field, with a single screening campaign … center for microbial NP drug
discovery, in multiple screening … reproducible NP dispensation new method was developed …
discovery, in multiple screening … reproducible NP dispensation new method was developed …