… molecular targets for the development of new therapeutic … of action of gold compounds
often involve enzyme inhibition, … than cisplatin and similar to auranofin. The IC 50 values for …

… compounds, or compounds that inhibit antioxidant systems [4]. … metals such has gold and
platinum (eg. auranofin and cisplatin… Glutathione S-transferase polymorphisms are associated …

… function as either scavengers of reactive species, or inhibitors of their … Lipids are primarily
targeted by ROS to initiate lipid … Au-drugs including Gold sodium thiomalate, Auranofin, and …

… The aim of present study was to investigate the anticancer … of various enzymes such as GPx,
glutathione S-transferase (GST), … of GPx) or 1 μM of Auranofin (inhibitor of TrxR) for 6 h were …

… , and β-cyclodextrin) with the aim of increasing the amount of … been recently addressed:
auranofin, an inhibitor of thioredoxin … part of detoxifying enzymes, like glutathione S-transferase. …

… alterations can be specifically targeted to enhance the activity of … pan-TXNRD inhibitor
Auranofin [65], a gold-containing anti-… , alkylating agents and platinum compounds as well as …

… enzyme in GSH synthesis and an antineoplastic target, is most frequently used to synergize
… Auranofin was identified in repurposing for the treatment of CLL inhibiting TrxR activity and …

… a glutathione-S-transferase targeting group and found the resulting product to be an effective
GST inhibitor (… Auranofin, a gold-based drug clinically used to treat rheumatoid arthritis, was …

… Auranofin (Ridaura) is one of the potent inhibitors of TrxR1 … a compelling putative therapeutic
target for cancer treatment, … oxidoreductase 1, GST glutathione-S-transferase, Nrf2 nuclear …

… ) sequences which is a target gene regulator in Thioredoxin … ; NAD(P)H, and Glutathione
S-transferase (Gst)17. Therefore, the … sulfoximine (BSO), and auranofin (Aur), and artesunate in …