Microtubule-Targeting Agents Induce ROS-Mediated Apoptosis in Cancer
A Das, S Paul, S Chakrabarty, M Dasgupta… - Handbook of Oxidative …, 2022 - Springer
… caspase-dependent apoptosis in the cancer cells. Thus, the microtubule targeting agents can
modulate mitochondrial ROS to induce apoptosis … a novel microtubule-modulating agent. J …
modulate mitochondrial ROS to induce apoptosis … a novel microtubule-modulating agent. J …
Discovery of a novel piperlongumine analogue as a microtubule polymerization inhibitor with potent anti-angiogenic and anti-metastatic efficacy
J Qin, H Li, X Wang, Y Zhang, Y Duan, Y Yao… - European Journal of …, 2022 - Elsevier
… This observation motivated us to explore whether II-14b interfere with the … Apoptosis induced
by II-14b may be caused by intrinsic caspase-dependent mitochondrial depolarization, and …
by II-14b may be caused by intrinsic caspase-dependent mitochondrial depolarization, and …
[HTML][HTML] The Noscapine Saga: Unravelling a Valuable Jewel from a Poppy Pod—Past, Present and Future
A Priyadarshani, R Bhatia, M Shan - Psychoactives, 2024 - mdpi.com
… It also induces changes in the potential of the mitochondrial … These proteins can activate
caspase-dependent apoptosis … role in triggering apoptosis via the mitochondrial pathways. This …
caspase-dependent apoptosis … role in triggering apoptosis via the mitochondrial pathways. This …
A proficient microwave synthesis with structure elucidation and the exploitation of the biological behavior of the newly halogenated 3-amino-1H-benzo [f] chromene …
… In our endeavors to develop novel and powerful agents with … and the induction of the
caspase dependent apoptosis. The … and the intrinsic/mitochondrial pathway. Our results are in …
caspase dependent apoptosis. The … and the intrinsic/mitochondrial pathway. Our results are in …
Rational design, chemical synthesis and cellular evaluation of novel 1, 3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents
… followed by apoptosis and appearance of apoptotic cells. Thus, … This unsatisfactory situation
has driven intensive research over … in cancer cells is then followed by induction of apoptosis. …
has driven intensive research over … in cancer cells is then followed by induction of apoptosis. …
Arsenic trioxide disturbs the LIS1/NDEL1/dynein microtubule dynamic complex by disrupting the CLIP170 zinc finger in head and neck cancer
L Gao, B Xue, B Xiang, KJ Liu - Toxicology and applied pharmacology, 2020 - Elsevier
… novel molecular target of ATO and demonstrate the capability and underlying mechanisms
of ATO as a potential antimetastatic agent … with the apoptosis of cancer cells induced by ATO …
of ATO as a potential antimetastatic agent … with the apoptosis of cancer cells induced by ATO …
Development of 9-(N-arylmethylamino) congeners of noscapine: the microtubule targeting drugs for the management of breast cancer
P Pragyandipta, MR Naik, B Bastia, PK Naik - 3 Biotech, 2023 - Springer
… Inhibition to cell cycle progression and induction of apoptosis … These derivatives induced
apoptosis by arresting cells at G2/… a novel therapeutic agent for the treatment of breast cancer. …
apoptosis by arresting cells at G2/… a novel therapeutic agent for the treatment of breast cancer. …