… and successfully solved its 3-dimensional structure. The structure shows that the 3 kindlin-3’s …
specifically recognizing activated human integrin αIIbβ3. The functional difference between …

… are important for kindlin self-… of kindlin-2 and kindlin-3, we identify kindlin-3 point mutations
that decrease self-association and enhance integrin binding, affording mutant kindlin-3 the …

… an important role in supporting integrin activation in a mouse … domain in kindlin-3 on the
development of LAD-III in humans … of kindlin-3 function in supporting integrin αIIbβ3 activation, …

… The kindlin family constitutes three members that have differential tissue… humans, the
importance of Kindlin3 (K3) is underscored by the lack of leukocyte adhesion and integrin activation…

… iii) possesses a high ligand affinity, which triggers integrin … Rap1a and Rap1b are Ras
subfamily members which share a … the ability of kindlin to support integrin αIIbβ3 activation [ 49 ] …

… integrin-α IIb β 3 in cells, but not to monomeric integrins in nanodiscs. Kindlin-3 binds to an
NPxY/F motif (NPKF in human β 2 ) … To assess the effect of kindlin-3 on β 2 -integrin activation …

… talin-1 and kindlin-3 enable integrin activation, with a focus on … type III exhibit normal integrin
expression but show mutations … point mutations in the F2 domain of kindlin-3 that perturbed …

… When a mutant form of kindlin-3, T 482 S 484 /AA kindlin-3, … support activation of integrin α
IIb β 3 , whereas wild-type kindlin-3 … Humans with kindlin-3 mutations or deficiency exhibit rare …

… The FERM-domain-containing kindlin family comprises three members, kindlin-1, kindlin-2 …
kindlin structures, and discuss the implication for integrin activation based on kindlin …

… called LAD-III, in which β1, β2, and β3 integrins are severely … Point mutations in the F0
subdomain impair integrin function … To minimize binding to integrins other than human LFA1, we …