Oral anticoagulants, old and new, are effective therapies for prevention and treatment of
venous thromboembolism and reduction of stroke risk in patients with atrial fibrillation.
However, blocking elements of the clotting cascade carries an inherent risk of bleeding.
Also, anticoagulated patients sometimes require urgent surgery or invasive procedures. This
has led to the emergence of a body of scientific literature on the reversal of anticoagulation
in these two settings. Traditionally, vitamin K antagonists (VKAs), which indirectly inactivate …