A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer
Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell
and thereby alter the function of nucleus. This leads to the generation of various protein
products to up or downregulate the cellular function. It is encoded by cell erythroblastosis
virus oncogene B1, so called C-erb B1/ERBB2/HER-2 gene that acts as a proto-oncogene. It
belongs to the HER-2 receptor-family in breast cancer and responds best with anti-Herceptin …
mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell
and thereby alter the function of nucleus. This leads to the generation of various protein
products to up or downregulate the cellular function. It is encoded by cell erythroblastosis
virus oncogene B1, so called C-erb B1/ERBB2/HER-2 gene that acts as a proto-oncogene. It
belongs to the HER-2 receptor-family in breast cancer and responds best with anti-Herceptin …
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