Autosomal dominant hypercalciuric hypocalcaemia: the calciumsensing receptor in renal calcium homeostasis and the impact of renal transplantation

JA Florance, JBW Schollum, A Pomeranc… - Internal Medicine …, 2024 - Wiley Online Library
… exocytosis and reduced breakdown or slowly (over days to weeks… in thyroid C cells, which
release calcitonin in response to … An inactivated CaSR allele results in (i) higher calcium levels …

Molecular regulation of calciumsensing receptor (CaSR)‐mediated signaling

L Tian, C Andrews, Q Yan… - Chronic Diseases and …, 2024 - Wiley Online Library
… and cell types, Ca2+ oscillations can be fast or slow with a … Secretion of PTH and calcitonin
by the parathyroid glands … from either one or two inactivating mutations in the CaSR gene. …

[PDF][PDF] Journal of Global Trends in Pharmaceutical Sciences

RK Cherian, P Beena, SP Raju - jgtps.com
… CaSR is believed to desensitize very slowly, beta-arrestins and … reduced secretion of calcitonin
from thyroid C cells mediated … In conclusion, the present work provides an important proof …

Implication of calcium supplementations in health and diseases with special focus on colorectal cancer

S Khan, SN Mosvi, S Vohra… - Critical Reviews in Clinical …, 2024 - Taylor & Francis
calcium levels, which prompts osteoclasts and bone cells to … Calcitonin provides the signals
to the osteoclasts to slow … in CRC by inactivating calcium-sensing receptor (CaSR) and up-…

The CalciumSensing Receptor (CaSR) in Disease

AN Keller, TM Josephs, KJ Gregory… - GPCRs as Therapeutic …, 2022 - Wiley Online Library
… can independently activate or inactivate the receptor. If such … in chief cells, one of two
parathyroid gland cell types with the … of hormones (including PTH and calcitonin), cytokines and …

Neuroendocrine cells initiate protective upper airway reflexes

LF Seeholzer, D Julius - Science, 2024 - science.org
… In this work, we show that murine NE cells in these compartments … and laryngeal NE cells
expressed calcitonin gene–related … NE cells with slowly and/or rapidly inactivating currents and …

Physiology of pancreatic β-cells: Ion channels and molecular mechanisms implicated in stimulus-secretion coupling

M Gil-Rivera, RM Medina-Gali, J Martínez-Pinna… - … Review of Cell and …, 2021 - Elsevier
inactivated. A hallmark of electrical activity in human cells is that, while it starts rapidly, it
is only slowly … This work has been encountering different difficulties, because of obtaining …

Role of calcium homeostasis in modulating EMT in cancer

CA Jones, LA Hazlehurst - Biomedicines, 2021 - mdpi.com
… the inhibition of calcitonin, a negative regulator of calcium [5]. … non-excitable cells, and usually
generate a much slower and … bound to integrins during transport ensures inactivation until …

Migraine: calcium channels and glia

M Kowalska, M Prendecki, T Piekut… - International journal of …, 2021 - mdpi.com
… (BBB), neuropeptides released in the TG, such as calcitonin gene-related peptide (CGRP), …
slow wave of depolarization followed by longer-lasting suppression of neurons and glial cells

Calcium-sensing receptor and voltage-gated potassium channel type 7 crosstalk: a potential therapeutic target for persistent neuropathic orofacial pain

N Chuinsir - 2023 - theses.ncl.ac.uk
… Kv7.2/7.3 channel inhibition in recombinant cell models, human … associated with upregulation
of calcitonin gene-related peptide (… Except where otherwise stated, the work in this thesis is …