Adaptation of a fluoroquinolone-sensitive Shigella sonnei to norfloxacin exposure

BC Wong, SKK Law… - Royal Society …, 2024 - royalsocietypublishing.org
… We observe a slight decrease in several r-protein promoters and postulate that the … to a
larger reduction from the RNA-seq analysis, suggesting that a decrease in the r-protein promoter …

Networks of resistance: Small RNA control of antibiotic resistance

DG Mediati, S Wu, W Wu, JJ Tree - Trends in Genetics, 2021 - cell.com
… of bacterial gene regulators termed regulatory small RNAs (sRNAs) and how they contribute
to antimicrobial resistance and tolerance. Small RNAs have notable roles in modulating the …

A fluoroquinolone-sensitive Shigella sonnei UKMCC1015 downregulates the expression of ribosomal proteins in response to sub-lethal concentration of norfloxacin

WB Chi, MZH Md Zoqratt, G I-Ning, Q Ayub, TH Siew - BioRxiv, 2020 - biorxiv.org
… to sublethal norfloxacin exposure, RNA-sequencing was performed on the fluoroquinolone-…
Since strain 5c showed reduced susceptibility to norfloxacin, we next examined the effects …

[HTML][HTML] Involvement of RNA chaperone hfq in the regulation of antibiotic resistance and virulence in Shigella sonnei

Y Wang, Y Teng, J Geng, J Long, H Yang, G Duan… - Research in …, 2023 - Elsevier
… , and kanamycin and a twofold decrease in resistance to amikacin, tobramycin, … decreasing
from 1024 μg/mL to 256 μg/mL, resulting in S. sonnei changing from resistant to sensitive to …

Molecular mechanism of Hfq-dependent sRNA1039 and sRNA1600 regulating antibiotic resistance and virulence in Shigella sonnei

Y Du, Y Wang, J Geng, J Long, H Yang, G Duan… - International Journal of …, 2024 - Elsevier
Small non-coding RNA (sRNA) plays a crucial role in regulating antibiotic resistance and …
under cefuroxime exposure, so it was hypothesized that sRNA1600 reduced the sensitivity of S. …

Small RNAs as fundamental players in the transference of information during bacterial infectious diseases

JJ González Plaza - Frontiers in Molecular Biosciences, 2020 - frontiersin.org
… These are short RNA species that carry out regulatory tasks in cis or trans. … found that at
decreasing levels of TolC mRNA the strain was less sensitive to antibiotics, such as norfloxacin. …

Virulence genes expression profiling of different Shigella flexneri serotypes in response to sub-inhibitory concentrations of azithromycin and ciprofloxacin

M Sadredinamin, M Shabani, A Karimi, MR Sohrabi… - Gut Pathogens, 2022 - Springer
… is a self-limiting disease that antibiotic therapy could decrease … The strain was sensitive to
noted antibiotic with low MIC … sub-MIC concentrations of norfloxacin culminate the ppGpp (a …

Antibiotic susceptibility of four Enterobacteriaceae strains (Enterobacter cloacae, Citrobacter freundii, Salmonella typhi and Shigella sonnei) isolated from wastewater …

AM Njoya, YP Yogne, JS Eheth, EBM Tamnou… - World Journal of …, 2021 - hal.science
… to Norfloxacin and of Ofloxacin. The proportion of strains of the 4 isolated species and which
were sensitive to … The decrease in membrane permeability or to the acquisition of resistant …

Comparative genome analysis of 12 Shigella sonnei strains: virulence, resistance, and their interactions

Z Zhu, L Wang, H Qian, F Gu, Y Li, H Zhang… - International …, 2021 - Springer
… All strains were sensitive to norfloxacin and most strains were … The number of ribosome RNA
(rRNA) and transfer RNA (… groups of virulence factors is reduced except for the three groups …

Resistance of gram-negative bacteria to current antibacterial agents and approaches to resolve it

Z Breijyeh, B Jubeh, R Karaman - Molecules, 2020 - mdpi.com
… and novel targets that resistant bacteria are sensitive to. Research efforts have been made
to … FQs are the best treatment for Shigella infection but antimicrobial resistance reduces the …