Advances of CCR5 antagonists: From small molecules to macromolecules
B Qi, Q Fang, S Liu, W Hou, J Li, Y Huang… - European Journal of …, 2020 - Elsevier
… TAK-779 is the only CCR5 antagonist with strong interaction … 3) is a dual chemokine receptor
(CCR2/CCR5) antagonist … can also act on CCR3 to activate eosinophils, but the activity is …
(CCR2/CCR5) antagonist … can also act on CCR3 to activate eosinophils, but the activity is …
Structural basis of chemokine and receptor interactions: Key regulators of leukocyte recruitment in inflammatory responses
… from their respective receptors CXCR4, CCR3, and CCR5 (… design of small molecules to
modulate chemokine receptors. … pockets in other chemokine receptors, including CCR1, CCR5, …
modulate chemokine receptors. … pockets in other chemokine receptors, including CCR1, CCR5, …
Profiling CCR3 target pathways for discovering novel antagonists from natural products using label-free cell phenotypic assays
H Chai, F Xu, J Wang, Y Zhang, X Xie, H Zhou… - Chemico-Biological …, 2023 - Elsevier
… of the CCR3 antagonist GW766994 in eosinophilic asthma did … DPC-168 is a potent CCR3
antagonist that causes CYP and … A small molecule antagonist of chemokine receptors CCR1 …
antagonist that causes CYP and … A small molecule antagonist of chemokine receptors CCR1 …
CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4
J Korbecki, K Kojder, D Simińska… - … journal of molecular …, 2020 - mdpi.com
… we discuss CC chemokine receptors CCR1, CCR2, CCR3, and CCR4 … H4 receptor and
therefore may act on eosinophils [55]. … CCL2 is also an antagonist of CCR3 [87]. CCL7 can also …
therefore may act on eosinophils [55]. … CCL2 is also an antagonist of CCR3 [87]. CCL7 can also …
Chemokines and chemokine receptors in allergic rhinitis: from mediators to potential therapeutic targets
Z Li, S Yu, Y Jiang, Y Fu - European Archives of Oto-Rhino-Laryngology, 2022 - Springer
… the infiltration of Th2 and eosinophils in LPR. ECs epithelial … Together, CCR1 and its ligand
CCL3 constitute a signal that … a CCR4 antagonist), and C19 (an antagonist of both CCR3 and …
CCL3 constitute a signal that … a CCR4 antagonist), and C19 (an antagonist of both CCR3 and …
CC chemokine receptor 4 (CCR4) as a possible new target for therapy
J Bogacka, K Pawlik, K Ciapała… - … Journal of Molecular …, 2022 - mdpi.com
… /CCR3/CCR5, and some chemokines activate only one … There was also an increase in the
expression of eosinophils, … several small molecule antagonists of the CCR4 receptor and have …
expression of eosinophils, … several small molecule antagonists of the CCR4 receptor and have …
CC-chemokine receptors CCR1, CCR2, CCR3, and CCR5 in inflammation
HA Halawa - 2023 - theses.gla.ac.uk
… Unfortunately, despite extensive research, no iCCR antagonists have been approved for …
the chemokine system, where individual leukocytes can express multiple chemokine receptors …
the chemokine system, where individual leukocytes can express multiple chemokine receptors …
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
… of CCR3 is associated with chemotaxis of eosinophils, thus … therapeutic small molecules
targeting any of these receptors … –G i interface among the complexes of CCL15–CCR1–G i (…
targeting any of these receptors … –G i interface among the complexes of CCL15–CCR1–G i (…
Role of chemokines and inflammatory cells in respiratory allergy
Y Bao, X Zhu - Journal of Asthma and Allergy, 2022 - Taylor & Francis
… Chemokine receptors may play a role in this complex process. Airway eosinophils have
reduced cell surface CCR3 and … At present, the use of CCR1, CCR2, CCR3 to interrupt AR and …
reduced cell surface CCR3 and … At present, the use of CCR1, CCR2, CCR3 to interrupt AR and …
[HTML][HTML] Blockade of CC chemokine receptor type 3 diminishes pain and enhances opioid analgesic potency in a model of neuropathic pain
K Pawlik, A Ciechanowska, K Ciapała… - Frontiers in …, 2021 - frontiersin.org
… Moreover, we determined how the blockade of CCR3 by its potent and selective antagonist
… via chemokine receptors, eg, J113863 - a CCR1 antagonist or cenicriviroc - a CCR2/CCR5 …
… via chemokine receptors, eg, J113863 - a CCR1 antagonist or cenicriviroc - a CCR2/CCR5 …