A Transcriptional Regulatory Map of Iron Homeostasis Reveals a New Control Circuit for Capsule Formation in Cryptococcus neoformans
Genetics, 2020•academic.oup.com
… More specifically, we found that Cir1 directly controls the expression of genes required
for iron acquisition and metabolism, and indirectly governs capsule formation by regulating
specific protein kinases, a regulatory connection not previously revealed. HapX regulates
the genes responsible for … In addition, our analysis revealed that Cir1 and HapX are iron-containing
proteins, with iron most likely present in the form of an Fe–S cluster. Importantly, our
analysis identified a new regulatory circuit by which Cir1 directly controls the expression of …
for iron acquisition and metabolism, and indirectly governs capsule formation by regulating
specific protein kinases, a regulatory connection not previously revealed. HapX regulates
the genes responsible for … In addition, our analysis revealed that Cir1 and HapX are iron-containing
proteins, with iron most likely present in the form of an Fe–S cluster. Importantly, our
analysis identified a new regulatory circuit by which Cir1 directly controls the expression of …
Abstract
To overcome host iron restriction, the human fungal pathogen Cryptococcus neoformans uses several iron uptake mechanisms to cause disease. In this study....
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