Why the first self-binding peptide of human c-Src kinase does not contain class II motif but can bind to its cognate Src homology 3 domain in class II mode?
P Zhou, F Yan, Q Miao, Z Chen… - Journal of Biomolecular …, 2021 - Taylor & Francis
… of intramolecular peptide recognition by its cognate target in … we herein proposed a new
mechanism that protein context is … to intramolecular domain–peptide recognition essentially. In …
mechanism that protein context is … to intramolecular domain–peptide recognition essentially. In …
Machine learning-guided evolution of BMP-2 knuckle Epitope-Derived osteogenic peptides to target BMP receptor II
W Zhang, J Liu, H Shan, F Yin, B Zhong… - … of Drug Targeting, 2020 - Taylor & Francis
… -II receptor extracellular domain (the BMP-2 binding domain) … be regarded as a self-binding
peptide to dynamically interact … knuckle peptide is necessary for the epitope recognition by …
peptide to dynamically interact … knuckle peptide is necessary for the epitope recognition by …
Molecular modeling and rational design of hydrocarbon-stapled/halogenated helical peptides targeting CETP self-binding site: Therapeutic implication for …
J Zhu, S Wei, L Huang, Q Zhao, H Zhu… - Journal of Molecular …, 2020 - Elsevier
… ), which has recognized as an important therapeutic target for … mechanism of stapling-improved
peptide binding was also … the binding energetics of native peptide to self-binding site by …
peptide binding was also … the binding energetics of native peptide to self-binding site by …
Rational design of stapled helical peptides as antidiabetic PPARγ antagonists to target coactivator site by decreasing unfavorable entropy penalty instead of …
Y Zhang, J Wang, W Li, Y Guo - European Biophysics Journal, 2022 - Springer
… to elucidate the underlying molecular mechanism. … the consensus recognition sequence
required for binding to the … peptides should share a similar binding mode to the domain, we …
required for binding to the … peptides should share a similar binding mode to the domain, we …
Directed molecular engineering of Mig6 peptide selectivity between proto-oncogene ErbB family receptor tyrosine kinases
Z Qiao, S Wang - Biotechnology and Bioprocess Engineering, 2021 - Springer
… We demonstrate that the Mig6 peptides not only inhibit EGFR, but also bind Her2, Her3, and
… ) A two-step binding mechanism for the self-binding peptide recognition of target domains. …
… ) A two-step binding mechanism for the self-binding peptide recognition of target domains. …
Integrated unsupervised–supervised modeling and prediction of protein–peptide affinities at structural level
P Zhou, L Wen, J Lin, L Mei, Q Liu… - Briefings in …, 2022 - academic.oup.com
… peptide recognition [21] and to characterize the approaching process of self-binding peptides
… to HLA-A*0201 allele and 50 scaffold peptides to the NHERF PDZ domain. These samples …
… to HLA-A*0201 allele and 50 scaffold peptides to the NHERF PDZ domain. These samples …
Targeting human Hippo TEAD binding interface with YAP/TAZ-derived, flexibility-reduced peptides in gastric cancer
D Wu, L Luo, Z Yang, Y Chen, Y Quan, Z Min - … Journal of Peptide …, 2021 - Springer
… , targeting YAP/TAZ–TEAD interaction has been recognized … domains at molecular level,
from which the domain binding … the conformation sampling of self-binding peptides (Zhou et al. …
from which the domain binding … the conformation sampling of self-binding peptides (Zhou et al. …
Rational molecular targeting of the inter-subunit interaction between human cardiac troponin hcTnC and hcTnI using switch peptide-competitive biogenic medicines
D Xiao, Z Fan, W Jiaqi, H Liu, L Shen, B He… - … Biology and Chemistry, 2020 - Elsevier
… targeting the core binding site (CBS) of hcTnC NTD domain. A … render peptide specific
recognition by hcTnC NTD domain. … Targeting self-binding peptides as a novel strategy to regulate …
recognition by hcTnC NTD domain. … Targeting self-binding peptides as a novel strategy to regulate …
A disordered encounter complex is central to the yeast Abp1p SH3 domain binding pathway
GJ Gerlach, R Carrock, R Stix, EJ Stollar… - PLoS Computational …, 2020 - journals.plos.org
… correct recognition sequence before completing the binding … SH3 domains bind disordered
proline-rich target peptides … However, with our two step binding model, we predict that …
proline-rich target peptides … However, with our two step binding model, we predict that …
Novel Antibacterial Targets in Protein Biogenesis Pathways
… on self-binding peptides (SBPs), which are short peptide segments that share primary sequence
with specific domains … During two-step transport, secretory proteins first cross the inner …
with specific domains … During two-step transport, secretory proteins first cross the inner …