Cryo-EM structures of the ATP release channel pannexin 1
Z Deng, Z He, G Maksaev, RM Bitter, M Rau… - Nature structural & …, 2020 - nature.com
… ATP, in addition to its classical role as the energy currency of living cells, is an important …
Broadly expressed, the plasma membrane ATP release channel PANX1 has been implicated in …
Broadly expressed, the plasma membrane ATP release channel PANX1 has been implicated in …
[HTML][HTML] Extracellular ATP: a feasible target for cancer therapy
V Vultaggio-Poma, AC Sarti, F Di Virgilio - Cells, 2020 - mdpi.com
… channel and its function as an ATP release channel [57]. The most direct evidence that
pannexin-1 is an ATP-permeable channel … The opening and activation of pannexin-1 channels …
pannexin-1 is an ATP-permeable channel … The opening and activation of pannexin-1 channels …
Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling
… of the Peizo1 channel can induce ATP release and regulate hDP-MSC migration, as we
have shown here for chemical activation of the Pieoz1 channel. Moreover, both ATP-induced …
have shown here for chemical activation of the Pieoz1 channel. Moreover, both ATP-induced …
[HTML][HTML] Physiopathological roles of vesicular nucleotide transporter (VNUT), an essential component for vesicular ATP release
N Hasuzawa, S Moriyama, Y Moriyama… - Biochimica et Biophysica …, 2020 - Elsevier
… in vesicular storage in ATP-secreting cells. … ATP release represents a major pathway for
purinergic chemical transmission, which had been mainly attributed to ATP permeation channels…
purinergic chemical transmission, which had been mainly attributed to ATP permeation channels…
[HTML][HTML] A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo
… For example, taking advantage of the permeability to Ca 2+ ions during ATP-gated P2X
channel opening, versatile tools were developed by fusing the genetically encoded Ca 2+ …
channel opening, versatile tools were developed by fusing the genetically encoded Ca 2+ …
Astrocyte Ca2+-evoked ATP release regulates myelinated axon excitability and conduction speed
J Lezmy, IL Arancibia-Cárcamo, T Quintela-López… - Science, 2021 - science.org
… ATP release from astrocytes, activation of adenosine receptors in the axon initial segment
and the nodes of Ranvier, increased cyclic AMP concentration, activation of HCN2 channels, …
and the nodes of Ranvier, increased cyclic AMP concentration, activation of HCN2 channels, …
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas
OH Petersen, JV Gerasimenko… - Physiological …, 2021 - journals.physiology.org
… channels changes to become inhibitory, closing the channels. As soon as the release channels
… level that stimulates the opening of the release channels. A new cycle can then begin. …
… level that stimulates the opening of the release channels. A new cycle can then begin. …
[HTML][HTML] ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels
… and demonstrated that channel activation by caspase cleavage … channel, albeit at a much
lower rate. We further show that Panx1 channels provide a molecular pathway for flux of ATP …
lower rate. We further show that Panx1 channels provide a molecular pathway for flux of ATP …
[HTML][HTML] Extracellular ATP as an inter-kingdom signaling molecule: release mechanisms by bacteria and its implication on the host
D Spari, G Beldi - International journal of molecular sciences, 2020 - mdpi.com
… (1) Channel-mediated ATP release occurs mainly via pannexin-1 channels and connexin-43
hemichannels [12,49]. Pannexin-1-dependent ATP release occurs in apoptotic cells, which …
hemichannels [12,49]. Pannexin-1-dependent ATP release occurs in apoptotic cells, which …
Mechanical stretch activates piezo1 in caveolae of alveolar type I cells to trigger ATP release and paracrine stimulation of surfactant secretion from alveolar type II cells
K Diem, M Fauler, G Fois, A Hellmann… - The FASEB …, 2020 - Wiley Online Library
… Stretch-induced Ca2+-signals depended on Ca2+-entry via piezo1 channels, activated
pannexin-1 hemichannels, and resulted in ATP release from ATI cells. ATP measurements with …
pannexin-1 hemichannels, and resulted in ATP release from ATI cells. ATP measurements with …
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