The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - … and targeted therapy, 2023 - nature.com
aneurysms to find new targets for diagnosis and treatment. To better understand aortic
aneurysm… Type I lesions extend from the ascending aorta to the abdominal aorta, and the lining of …

Novel pharmacological approaches in abdominal aortic aneurysm

L Puertas-Umbert, R Almendra-Pegueros… - Clinical …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health …
need for therapy. This disease is featured by a progressive dilation of the abdominal aorta, …

Mechanisms of abdominal aortic aneurysm progression: A review

JP Gao, W Guo - Vascular Medicine, 2022 - journals.sagepub.com
… Up to now, there is still controversy on the choice of treatment method of AAA. Even so,
the mechanisms of AAA progression are poorly defined, making targeting new therapies

Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
… Research over the past decade has identified novel contributors to aneurysmabdominal
aortic aneurysm growth and efforts underway to develop effective pharmacological treatments

A novel mechanism underlying inflammatory smooth muscle phenotype in abdominal aortic aneurysm

D Cai, C Sun, G Zhang, X Que, K Fujise… - Circulation …, 2021 - Am Heart Assoc
… MMP2 and MMP9 mRNA levels were assessed by RT-PCR at 0, 2, 4, and 6 h following the
treatment (F) and normalized to the mean level before the actinomycin treatment (0 h), which …

Promising novel therapies in the treatment of aortic and visceral aneurysms

TM Stougiannou, KC Christodoulou… - Journal of Clinical …, 2023 - mdpi.com
… Atherosclerosis, although more frequently implicated in descending thoracic and abdominal
aortic aneurysms, might also be an etiologic factor for TAAAs and VAAs [13,14], while …

Development of pharmacotherapies for abdominal aortic aneurysms

LM Weaver, CD Loftin, CG Zhan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
… The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms (AAA).
This inflammatory disease often goes undiagnosed until a late stage and associated …

Immune and inflammatory mechanisms of abdominal aortic aneurysm

AC Marquez-Sanchez, EK Koltsova - Frontiers in immunology, 2022 - frontiersin.org
… , understanding of novel immune mediated mechanisms regulating AAA development and
factors driving pathogenic immune cell activation will pave the road for novel therapeutics and …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
… and therapies to limit AAA growth. Genome-wide association studies have identified novel
drug targets… Mendelian randomization analyses suggest that treatments to reduce low-density …

[HTML][HTML] Innovation in pathogenesis and management of aortic aneurysm

M Barkhordarian, HHV Tran, A Menon… - World Journal of …, 2024 - ncbi.nlm.nih.gov
… We also highlighted the novel management methods that … thoracic aortic aneurysm (TAA),
abdominal aortic aneurysms (… to aortic aneurysms has a dynamic landscape of treatment