… CFTR was mainly expressed in airway submucosal glands … used to measure CFTR-dependent
Cl − secretion in jejunal tissue. … role of defective CFTR-dependent ion transport and acidic …

… due to activation of CFTR-dependent Cl- secretion. The CFTR … by shifting airway transport
toward fluid secretion and … sense since submucosal glands are the true place of secretion. …

… of diminished CFTR-dependent chloride and fluid secretion by the airway … Submucosal
glands are mainly located in the upper airways and consist of gland acini, which secrete fluid, …

… of the airway fluid is derived from submucosal glands (SMGs… enzymatically into single or
clustered acinar cells. Details are … of IND on CFTR-dependent pH and fluid secretion changes …

… airway surface liquid had a reduced ability to kill bacteria, consistent with SMG production of
antimicrobials. In wild-type pigs, SMGs secrete mucus that emerges onto the airway … Acinar …

… in liquid lining the airway surface. The results indicate that succinate migrates down the
submucosal gland duct to the acinus, … receptors, causing PNECs to release ATP. The short-range …

… the submucosal gland acini [209]. Mucous cells on the airway surface produce and secrete
… the titration and fine-tuning of CFTR-dependent physiological responses to various envi…

… secretion in human bronchioles [45]. However, it has been noted that muscarinic responses
of fluid secretion are reduced in submucosal glands … serous acinar cells. Am J Physiol Lung …

… , reduced CFTR-dependent bicarbonate secretion has been … , including impaired MCC, acinar
and alveolar hyperinflation, … submucosal glands throughout the cartilaginous airways, and …