Role of neuropeptides in orofacial pain: A literature review

J Wang, X Liu, J Gou, J Deng, M Li… - Journal of Oral …, 2024 - Wiley Online Library
pain encompasses dental pain, temporomandibular joint (… A mice experiment demonstrated
that CGRP upregulated … C; SP, substance P; TRPM3, transient receptor potential cation …

Role of neurotrophins in orofacial pain modulation: a review of the latest discoveries

F Bonomini, G Favero, S Castrezzati… - International journal of …, 2023 - mdpi.com
allodynia of the inflamed temporomandibular joint (TMJ) in … in an inflammatory soup-induced
trigeminal allodynia in a rat … upregulates TrkB through a paracrine/autocrine mechanism, …

Neuroimmune interactions in painful TMD: mechanisms and treatment implications

Y Yi, X Zhou, X Xiong, J Wang - Journal of Leukocyte Biology, 2021 - academic.oup.com
… of temporomandibular joint (TMJ), and neurogenic … rat model, TNF-α promotes nociception
in trigeminal ganglia … peptide (CGRP), substance P (SP), and so on, and contribute to local …

Exploring the roles of neuropeptides in trigeminal neuropathic pain: A systematic review and narrative synthesis of animal studies

N Chuinsiri, D Edwards, V Telezhkin, CJ Nile… - Archives of Oral …, 2021 - Elsevier
… Calcitonin gene-related peptide (CGRP) and substance P were … on orofacial mechanical
sensitivity and SP expression in rats. … The paracrine effect of CGRP has been shown on satellite …

Cross-talk signaling in the trigeminal ganglion: role of neuropeptides and other mediators

K Messlinger, LK Balcziak, AF Russo - Journal of neural transmission, 2020 - Springer
… of neurokinin-1 (NK1) receptors, receptors for substance P, has indirectly been shown by
functional studies in the rat trigeminal ganglion. … temporomandibular joint and facial skin was …

Multi-dimensional role of the parabrachial nucleus in regulating pain-related affective disturbances in trigeminal neuropathic pain

A Katagiri, T Kato - Journal of Oral Science, 2020 - jstage.jst.go.jp
… tissues, including the temporomandibular joint and masseter … related peptide (CGRP),
substance P, and neuropeptide Y are … tion to the rat brain stem sensory trigeminal nuclear complex …

Pathophysiology of post-traumatic trigeminal neuropathic pain

OA Korczeniewska, D Kohli, R Benoliel… - Biomolecules, 2022 - mdpi.com
… shown to contribute to orofacial neuropathic pian via CXCR5/… via activation of p38 MAPK in
the trigeminal ganglion of mice [… site of injury and the dorsal root ganglion (DRG) that induces …

Resveratrol alleviates temporomandibular joint inflammatory pain by recovering disturbed gut microbiota

Y Ma, S Liu, H Shu, J Crawford, Y Xing, F Tao - Brain, behavior, and …, 2020 - Elsevier
… chose male mice in … contributes to CFA-induced TMJ inflammation through reducing the
production of SCFAs in the gut, impairing BBB integrity and activating microglia in the trigeminal

A systematic review of rat models with temporomandibular osteoarthritis suitable for the study of emerging prolonged intra-articular drug delivery systems

R Nicot, F Barry, H Chijcheapaza-Flores… - Journal of Oral and …, 2021 - Elsevier
… invasive therapies for temporomandibular joint osteoarthritis (… release of substance P from
the trigeminal root ganglion neurons … innervating the facial skin via the paracrine mechanism

Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception

Y Jang, M Kim, SW Hwang - Journal of Neuroinflammation, 2020 - Springer
… stimulate the innervating neurons in a paracrine fashion [6]. In … A comparison study using
transgenic mice (wild-type miceSubstance P (SP) is a peptidergic neurotransmitter released …