The activation of the G protein-coupled estrogen receptor (GPER) prevents and regresses cardiac hypertrophy

RA Di Mattia, JIE Mariángelo, PG Blanco, CJ De Giusti… - Life sciences, 2020 - Elsevier
… eosin for determining cardiomyocyte cross-sectional area (… GPER blockers G-15 (1 μmol/L)
or G-36 (1 μmol/L) inhibited … that MR activation leads to oxidative stress and apoptosis [24]…

Estrogen receptors: therapeutic perspectives for the treatment of cardiac dysfunction after myocardial infarction

JS da Silva, TL Montagnoli, BS Rocha… - International journal of …, 2021 - mdpi.com
GPER activation also demonstrates anti-inflammatory effects … κB activity, through modulation
of inhibitor of κB kinases (IKK) … as E2 also reduces cardiomyocyte apoptosis in the infarction …

G protein‐coupled estrogen receptor 1: a novel target to treat cardiovascular disease in a sex‐specific manner?

QN Dinh, A Vinh, TV Arumugam… - British Journal of …, 2021 - Wiley Online Library
… The GPER activates G proteins to stimulate various signalling … GPER signalling may
also inhibit the production of arginine … in the early (infarction and apoptosis) and later (fibrosis) …

GPER mediates estrogen cardioprotection against epinephrine-induced stress

L Fu, H Zhang, JO Machuki, T Zhang… - Journal of …, 2021 - joe.bioscientifica.com
estrogen receptor (GPER) executes the rapid effects of … against cardiac insult and apoptosis
by suppressing cardiac contraction… is that activation of GPER had no effect on cardiomyocyte

Nuclear receptors in myocardial and cerebral ischemia—mechanisms of action and therapeutic strategies

J Rzemieniec, L Castiglioni, P Gelosa… - International Journal of …, 2021 - mdpi.com
… and evokes an activation of apoptosis or inflammation in … GPER-1 may become the
predominant estrogen receptor … or AhR knockdown can affect cardiomyocyte differentiation via …

Female heart health: is GPER the missing link?

L Groban, QK Tran, CM Ferrario, X Sun… - Frontiers in …, 2020 - frontiersin.org
estrogen receptor, G protein-coupled estrogen receptor (… chain efficiency; reducing
apoptotic leakage of cytochrome C; … Our data from the novel cardiomyocyte-specific GPER KO …

Er-xian ameliorates myocardial ischemia-reperfusion injury in rats through RISK pathway involving estrogen receptors

M Qiang, HAO Jiping, LIU Huihui, YIN Jia… - Chinese journal of …, 2022 - Elsevier
… opening, and decreased cardiomyocyte apoptosis. We found that … estrogen receptor 30
(GPER 30) are three vital estrogen … Therefore, we used estrogen receptor inhibitors ICI 182780 …

The G protein-coupled oestrogen receptor GPER in health and disease: an update

ER Prossnitz, M Barton - Nature Reviews Endocrinology, 2023 - nature.com
GPER can either activate or inhibit NF-κB transcriptional activity, depending on the cellular
… compared with GPER in cells that express multiple oestrogen receptors 77 . Of these GPER-…

The role of estrogen receptors in cardiovascular disease

L Aryan, D Younessi, M Zargari, S Banerjee… - International journal of …, 2020 - mdpi.com
… 1 or GPER) has also gained increased research attention over … nitric oxide synthase (NOS)
inhibitor, which suggests that NO … -specific promotion of cardiomyocyte apoptosis—with male …

Glucocorticoid inhibition of estrogen regulation of the serotonin receptor 2B in cardiomyocytes exacerbates cell death in hypoxia/reoxygenation injury

HA Dhaibar, NG Carroll, S Amatya… - Journal of the …, 2021 - Am Heart Assoc
… In our study, we proposed for the first time a novel mechanism … ; G‐protein‐coupled estrogen
receptor [GPER/GPR30] antagonist). … an increase in cardiomyocyte apoptosis in response to …