The activation of the G protein-coupled estrogen receptor (GPER) prevents and regresses cardiac hypertrophy
… eosin for determining cardiomyocyte cross-sectional area (… GPER blockers G-15 (1 μmol/L)
or G-36 (1 μmol/L) inhibited … that MR activation leads to oxidative stress and apoptosis [24]…
or G-36 (1 μmol/L) inhibited … that MR activation leads to oxidative stress and apoptosis [24]…
Estrogen receptors: therapeutic perspectives for the treatment of cardiac dysfunction after myocardial infarction
JS da Silva, TL Montagnoli, BS Rocha… - International journal of …, 2021 - mdpi.com
… GPER activation also demonstrates anti-inflammatory effects … κB activity, through modulation
of inhibitor of κB kinases (IKK) … as E2 also reduces cardiomyocyte apoptosis in the infarction …
of inhibitor of κB kinases (IKK) … as E2 also reduces cardiomyocyte apoptosis in the infarction …
G protein‐coupled estrogen receptor 1: a novel target to treat cardiovascular disease in a sex‐specific manner?
… The GPER activates G proteins to stimulate various signalling … GPER signalling may
also inhibit the production of arginine … in the early (infarction and apoptosis) and later (fibrosis) …
also inhibit the production of arginine … in the early (infarction and apoptosis) and later (fibrosis) …
GPER mediates estrogen cardioprotection against epinephrine-induced stress
L Fu, H Zhang, JO Machuki, T Zhang… - Journal of …, 2021 - joe.bioscientifica.com
… estrogen receptor (GPER) executes the rapid effects of … against cardiac insult and apoptosis
by suppressing cardiac contraction… is that activation of GPER had no effect on cardiomyocyte …
by suppressing cardiac contraction… is that activation of GPER had no effect on cardiomyocyte …
Nuclear receptors in myocardial and cerebral ischemia—mechanisms of action and therapeutic strategies
J Rzemieniec, L Castiglioni, P Gelosa… - International Journal of …, 2021 - mdpi.com
… and evokes an activation of apoptosis or inflammation in … GPER-1 may become the
predominant estrogen receptor … or AhR knockdown can affect cardiomyocyte differentiation via …
predominant estrogen receptor … or AhR knockdown can affect cardiomyocyte differentiation via …
Female heart health: is GPER the missing link?
… estrogen receptor, G protein-coupled estrogen receptor (… chain efficiency; reducing
apoptotic leakage of cytochrome C; … Our data from the novel cardiomyocyte-specific GPER KO …
apoptotic leakage of cytochrome C; … Our data from the novel cardiomyocyte-specific GPER KO …
Er-xian ameliorates myocardial ischemia-reperfusion injury in rats through RISK pathway involving estrogen receptors
M Qiang, HAO Jiping, LIU Huihui, YIN Jia… - Chinese journal of …, 2022 - Elsevier
… opening, and decreased cardiomyocyte apoptosis. We found that … estrogen receptor 30
(GPER 30) are three vital estrogen … Therefore, we used estrogen receptor inhibitors ICI 182780 …
(GPER 30) are three vital estrogen … Therefore, we used estrogen receptor inhibitors ICI 182780 …
The G protein-coupled oestrogen receptor GPER in health and disease: an update
ER Prossnitz, M Barton - Nature Reviews Endocrinology, 2023 - nature.com
… GPER can either activate or inhibit NF-κB transcriptional activity, depending on the cellular
… compared with GPER in cells that express multiple oestrogen receptors 77 . Of these GPER-…
… compared with GPER in cells that express multiple oestrogen receptors 77 . Of these GPER-…
The role of estrogen receptors in cardiovascular disease
… 1 or GPER) has also gained increased research attention over … nitric oxide synthase (NOS)
inhibitor, which suggests that NO … -specific promotion of cardiomyocyte apoptosis—with male …
inhibitor, which suggests that NO … -specific promotion of cardiomyocyte apoptosis—with male …
Glucocorticoid inhibition of estrogen regulation of the serotonin receptor 2B in cardiomyocytes exacerbates cell death in hypoxia/reoxygenation injury
HA Dhaibar, NG Carroll, S Amatya… - Journal of the …, 2021 - Am Heart Assoc
… In our study, we proposed for the first time a novel mechanism … ; G‐protein‐coupled estrogen
receptor [GPER/GPR30] antagonist). … an increase in cardiomyocyte apoptosis in response to …
receptor [GPER/GPR30] antagonist). … an increase in cardiomyocyte apoptosis in response to …