… receptor pathways (α1-adrenoceptors and 5-HT receptors) might be involved in the biological
action … are other compounds besides parthenolide, with biological activity that could be …

… parthenolide presented between 10 % and 20 %, whilst almost no transport was detected for
lactucopicrin. Furthermore, costunolide and parthenolide … costunolide and parthenolide as …

… , the blockade of the 5-HT2A and 5-HT2C receptors was found … scan mode to identify the
parthenolide, and the MS spectrum … to improve our knowledge about the mechanism of action. …

… activity of a half synthetic parthenolide derivate. As it will be demonstrated, the wide range of
biological activities of parthenolide, … C, strong binding to 5-HT2A receptor) • Inhibition of the …

… activity, thrombocyte activity, and possess the ability to inhibit the binding of serotonin to
their receptors. Its … Activity of parthenolide at 5HT2A receptors. J Nat Prod. 1997;60:651-653. …

… Despite the promising targeted activity of parthenolide upon various migraine targets in vivo
… the multiple migraine targets of parthenolide in feverfew supports further investigation into …

… In addition, 5-HT2A receptor expression was unchanged in CTB-SAP rats versus controls, …
ROS formation via NADPH oxidase activity, as ROS disinhibits phosphatase action on PKC (ie…

This study aimed to investigate, through in vivo and biochemical methodologies, the effect of
trans,trans-farnesol (12.5, 25, 50 or 100 mg/kg, po) acute administration, adopting different …

… activity of NLRP3 contributes to the development and progression of epilepsy [68,70,71,73,74,75,117];
hence, inhibiting the activity … Natural products such as parthenolide and oridonin …

… They supply nutrients, provide physical support for neural development, and modify the
interneural synaptic activity through neuroglial signaling and specific neurotransmitters, namely …