Healthy-like CD4+ Regulatory and CD4+ Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion
J Schneider, L Kuhlmann, Y Xiao, S Raha… - International Journal of …, 2022 - mdpi.com
… CD3 + TCR repertoire analysis after alloHSCT, reduced diversity and clonal expansion were
observed in acute GVHD … Finally, we assessed the predictive potential of repertoire diversity …
observed in acute GVHD … Finally, we assessed the predictive potential of repertoire diversity …
Cytotoxicity of donor natural killer cells to allo-reactive T cells are related with acute graft-vs.-host-disease following allogeneic stem cell transplantation
L Sheng, Q Mu, X Wu, S Yang, H Zhu, J Wang… - Frontiers in …, 2020 - frontiersin.org
… , and investigated their relationship with acute GVHD (… of donor NK cells on the proliferation
of autogeneic CD3 + T … the main reasons why the predictive value of the donor NK CD107a …
of autogeneic CD3 + T … the main reasons why the predictive value of the donor NK CD107a …
[HTML][HTML] … between CD34+ and CD3+ T-cells in allogeneic grafts and acute graft-versus-host disease in children undergoing allogeneic hematopoietic stem cell …
D Yao, B Li, X Chu, J Pan, L Meng, Y Hu, L Gao… - Transplant …, 2023 - Elsevier
… Acute graft-versus-host disease (aGVHD) is a major … to determine the predictive value of
the graft cell subsets for the … hematopoietic recovery and stable full donor chimerism, with the …
the graft cell subsets for the … hematopoietic recovery and stable full donor chimerism, with the …
Evaluation of risk factors for and subsequent mortality from poor graft function (PGF) post allogeneic stem cell transplantation
A Prabahran, R Koldej, L Chee, E Wong… - Leukemia & …, 2021 - Taylor & Francis
… This analysis identifies risk factors predictive of PGF and … donor chimerism had poorer
outcomes, we decided to evaluate our … Using the three variables of grade 3–4 acute GVHD, …
outcomes, we decided to evaluate our … Using the three variables of grade 3–4 acute GVHD, …
CD52‐negative T cells predict acute graft‐versus‐host disease after an alemtuzumab‐based conditioning regimen
…, D Kriege, M Theobald, T Bopp… - British journal of …, 2020 - Wiley Online Library
… chimerism and replenish the CD52 pos T-cell pool after … of CD3 pos CD4 pos , CD3
pos CD8 pos T cells and Tregs … and CD52 pos Tregs at day +50 as a predictive marker for …
pos CD8 pos T cells and Tregs … and CD52 pos Tregs at day +50 as a predictive marker for …
Bone marrow CD34+ molecular chimerism as an early predictor of relapse after allogeneic stem cell transplantation in patients with acute myeloid leukemia
M Malagola, N Polverelli, A Beghin, F Bolda… - Frontiers in …, 2023 - frontiersin.org
… Whenever clinically possible (no graft versus host disease and … to full donor chimerism or
increase in the percentage of donor … Quantitative chimerism in CD3-negative mononuclear cells …
increase in the percentage of donor … Quantitative chimerism in CD3-negative mononuclear cells …
… or preemptive low-dose azacitidine and donor lymphocyte infusion to prevent disease relapse following allogeneic transplantation in patients with high-risk acute …
T Guillaume, S Thépot, P Peterlin, P Ceballos… - … and Cellular Therapy, 2021 - Elsevier
… of grade II-IV acute GVHD and chronic GVHD were 27.4% and … mitigate GVHD through the
expansion of regulatory T cells … chimerism analysis showed that mixed CD34 + BM or CD3 + …
expansion of regulatory T cells … chimerism analysis showed that mixed CD34 + BM or CD3 + …
Lower Absolute Lymphocyte Count Before Conditioning Predicts High Relapse Risk in Patients After Haploidentical Peripheral Blood Stem Cell Transplantation With …
X Zhou, Y Cai, J Yang, Y Tong, H Qiu… - Cell …, 2022 - journals.sagepub.com
… post-transplant seemed to be a strong predictor for relapse and poor … Acute GvHD (aGvHD)
and chronic GvHD (cGvHD) were … alloreactive donor T lymphocytes that mediate GvHD 26 . …
and chronic GvHD (cGvHD) were … alloreactive donor T lymphocytes that mediate GvHD 26 . …
[HTML][HTML] … detection rather than mixed chimerism predicts relapses after allogeneic stem cell transplantation for intermediate-risk acute myelogenous leukemia patients …
E Klyuchnikov, A Badbaran, R Massoud… - … and Cellular Therapy, 2022 - Elsevier
… have greater predictive value for relapse than mixed chimerism (MC… Full donor chimerism
(FDC) can correspond to successful … chimerism (eg, T cell, CD34 + , CD3 - ) have shown better …
(FDC) can correspond to successful … chimerism (eg, T cell, CD34 + , CD3 - ) have shown better …
Poor graft function after T cell-depleted allogeneic hematopoietic stem cell transplant
R Reich-Slotky, N Al-Mulla, R Hafez… - Leukemia & …, 2020 - Taylor & Francis
… The lower level of CD3 donor chimerism is a result of T cell depletion. The median … , acute
GVHD and CMV viremia are major predictors of PGF in the first 100 days after T cell depleted …
GVHD and CMV viremia are major predictors of PGF in the first 100 days after T cell depleted …