… measured the effect of FK506 on LTP in acute hippocampal slices. By stimulating mossy fibers,
… reversed deficits in cognition and memory in Tg2576 APP transgenic mice as well as AD …

… Transgenic (Tg2576) mice intraperitoneally (IP) injected with … inhibition with CNI, in which
CNI was shown to restore dendritic … Acute and subacute treatment with intraperitoneal CsA …

… and early symptomatic Tg2576 mice, and that restoring proper … hAPP transgene in the mouse
genome warrants that APP is … icv or ip injections of the inhibitor of eIF2α dephosphorylation, …

… We show that in Tg2576 mice, DA neurons of the VTA at the … treatment of Tg2576 mice with
Nilotinib, a validated c-Abl inhibitor, … Acute brain slices were obtained following halothane …

… learning and memory. In Alzheimer’s disease β-amyloid (Aβ) oligomers may impair learning
and memory by … of the kinase PKA or phosphatase Calcineurin (CaN) to the postsynaptic …

… activation in APP/PS1 mice due to the transgenic mutations … WT mice which was restored
to normal in APP/PS1 mice treated … improved fear-conditioning in Tg2576 mice, an AD model …

… that the inhibition of … , Tg2576 mice with Swedish APP mutation [27] were ablated of HCK
and studied at 10–12 months old. As such, the younger J20 mice with different APP transgene …

… The CAMKII and the calcium-dependent phosphatase calcineurin (CaN) … inhibition of CaN
in Tg2576 APP transgenic mice showed an improvement in associative learning and memory […

… Similarly, transgenic mice expressing klotho had higher … but were restored to normal levels
in AD mice expressing BDNF. … Nonetheless, the inhibition calcineurin and STEP are already …

… the negative modulation auto-inhibitory domain. Therefore, in this model of dementia, in
agreement with transgenic models of AD and findings in AD, we observed an activation of CaN. …