… tACS treatment is to restore these fundamental oscillations for … associated to cell death in
DAergic neurons of Tg2576 mice, … during patch-clamp recordings from acute midbrain slices. As …

… Suppression of CN signaling using drugs or transgenic approaches ameliorates several
key phenotypes associated with AD including neuronal degeneration [11], synapse loss/…

… neurons inhibited autophagy through activation of calcineurin and the resulting inhibition of
… Because of the less severe phenotype, we compared amyloid load in hippocampal region …

… , WT and transgenic. Pilot studies determined that male and female … were acutely treated
with the calcineurin (CaN) inhibitor, … Tg2576 hippocampus-dependent associative learning and …

… Since the levels of Ca 2+ are increased by activating calcineurin (… attenuated cognitive
decline by restoring the metabolic balance … by inhibitors or Aβ in APP and Tg2576 mice [28,180]. …

… Tg2576-APP swe mice, and restores spatial learning and … can rescue the fear memory
of transgenic APP/ PS1 mice of … inhibition of astrocytes, we found the restored short-term …

… β deposits, neuroinflammation and severe brain atrophy. … Area (VTA) and can be restored
by L-DOPA treatment. Due to the … in Tg2576 mice, we compared neurons from WT and Tg2576 …

… levels or plaque load in the PS/APP and Tg2576 strains [20, 21], … The restoration of glucose
metabolism in both the SLM and … in App NL-GF mice and published findings from transgenic …

… chronically with the calcineurin inhibitor FK506 have been … protection in APP/PS1 double
transgenic mice [101,102]. … is elevated in the brain capillaries of TG2576 AD model mice, and is …

… (in mild to severe AD) are the cholinesterase inhibitors FDA-… of mice depositing amyloid
plaques (Tg2576 AD model) led to a … 2+ overload in transgenic neurites, restoring them to control …