… Studies on the APP/PS1 transgenic mouse model revealed a significant increase in the …
on neurotransmission, and inhibition of CDK5 activity, by either acute or genetic means leads to …

… In particular, iron levels can accelerate the activity of calcineurin … Moreover, Fpn1 restoration
and in vitro inhibition of … In addition, in vivo study on Tg2576 APP transgenic mice, the oral …

… influx, calcium-dependent activation of calcineurin/PP2B, and its … tau phosphorylation in
Tg2576 AD transgenic mice. Besides … ) have also been reported to inhibit the fibrillization and/or …

… calcium homeostasis activates calcineurin (CaN) and … gene was shown to completely restore
cognitive decline and cellular … Moreover, AD transgenic mice overexpressing S100B exhibit …

… APP/PS1 transgenic mice were utilized to establish mouse … microglia and hippocampal
tissues of APP/PS1 mice. MiR-… of Tg2576 mice, and suppression of miR-124 reverses memory …

… Data from different transgenic lines of AD mice suggest that … inhibitory avoidance paradigm,
a fear-motivated learning task. In the step-down inhibitory avoidance task, animals associate …

… resultant learning and memory. In fact, CaMKII knock-out (KO) mice were the first transgenic
mouse … Markedly, this study found that acute inhibition of CaN (using FK506) increased the …

… associated with holistic neuronal function and helps in formation and maintenance of memory
and learning … Traditional HDAC inhibitors are divided into four groups such as short-chain …

… conditions, Aβ can inhibit the excessive activation of … + /calmodulin-dependent phosphatase
calcineurin (CaN) and glycogen … Tg2576 transgenic mice [132]. Brain-derived Aβ*56 causes …

… effects associated with calcineurin inhibitors that result from inhibition of calcineurin in …
reduce acute induction of hypertension by CsA in mice (Zhang et al. 2000). In summary, …