[PDF][PDF] Cryptic insertion of CBFB into MYH11 leading to a type D fusion in acute myeloid leukemia with normal karyotype

K Yamamoto, K Kurata, A Kitao, R Sakai… - International Journal …, 2022 - da.lib.kobe-u.ac.jp
… the patient as having AML M4Eo and AML with CBFB-MYH11 in FAB and World Health …
Acute myeloid leukaemia (FAB AML-M4Eo) with cryptic insertion of cbfb resulting in cbfb-Myh11

Cytogenetically masked CBFB-MYH11 fusion and concomitant TP53 deletion in a case of acute myeloid leukemia with a complex karyotype

B Ducourneau, L Fenwarth, N Duployez… - Leukemia & …, 2020 - Taylor & Francis
… Six other cases with cryptic insertions leading to a CBFB-MYH11AML and atypical morphology
not suggestive of acute monocytic leukemia with abnormal eosinophils (M4Eo-FAB) and …

Integrative immunophenotypic and genetic characterization of acute myeloid leukemia with CBFB rearrangement

F Sameeta, SA Wang, Z Tang, JD Khoury… - American Journal of …, 2024 - academic.oup.com
… of acute myeloid leukemia (AML) with CBFB rearrangement and correlate the … Acute
myeloid leukaemia (FAB AML-M4Eo) with cryptic insertion of cbfb resulting in cbfb-Myh11 fusion. …

Detection of a novel CBFB-MYH11 fusion transcript in acute myeloid leukemia M1 with inv (16)(p13q22)

K Kurata, K Yamamoto, Y Okazaki, Y Noguchi, K Matsui… - Cancer Genetics, 2020 - Elsevier
AML-M4Eo according to the French–American–British (FAB) … Furthermore, two candidates
of cryptic recombination signal … exon 27 breakpoint and 13-bp insertion at the fusion point …

CBFB break-apart FISH testing: an analysis of 1629 AML cases with a focus on atypical findings and their implications in clinical diagnosis and management

RK Yang, GA Toruner, W Wang, H Fang, GC Issa… - Cancers, 2021 - mdpi.com
… , a positive RT-PCR result with a percentage of CBFB-MYH11 transcripts below 4.2% was …
CBFB was inserted into MYH11. In general, rearrangement caused by insertion is often cryptic

Truncated runx1 generated by the fusion of runx1 to antisense grik2 via a cryptic chromosome translocation enhances sensitivity to granulocyte colony-stimulating …

A Abe, Y Yamamoto, A Katsumi, H Yamamoto… - … and Genome Research, 2020 - karger.com
… with acute myeloid leukemia, inv(16)(p13;q22)/CBFB-MYH11 (FAB classification M4Eo). He
… the reader is urged to check the package insert for each drug for any changes in indications …

The genomics of acute myeloid leukemia in children

SE Conneely, RE Rau - Cancer and Metastasis Reviews, 2020 - Springer
… ), the fusion gene CBFB-MYH11, composed of exons 1–5 of CBFB and exons 12–41 of …
with M4Eo, myelomonocytic AML with aberrant eosinophils, though a variety of FAB types can be …

Genetic characterization and risk stratification of acute myeloid leukemia

F Pourrajab, MR Zare-Khormizi… - Cancer management …, 2020 - Taylor & Francis
… /AML1 and CBFB-MYH11 impair myeloid differentiation and induce … M2 FAB subtype (AML
with maturation), but rarely seen with … is a cryptic amplification and frequently amplified in AML

Diagnosis and Classification of AML: WHO 2016

MT Voso, E De Bellis, T Ottone - Acute Myeloid Leukemia, 2021 - Springer
… features of the M4Eo subtype of the FAB classification. Blasts … generates the chimeric fusion
gene CBFB-MYH11. The gene … insertion of RARA into PML has been described: the result is …

Cytogenetics of pediatric acute myeloid leukemia: a review of the current knowledge

J Quessada, W Cuccuini, P Saultier, M Loosveld… - Genes, 2021 - mdpi.com
… (FAB) cooperative group proposed an AML classification … , AML M4Eo/inv(16)(p13q22)
is now referred to as AML with … , as suggested in our proposed workflow, such as CBFB-MYH11