… be developed clinically, including adeno-associated virus (AAV), … An angiogenesis-targeting
and non-viral gene delivery … Approximately 100% of supporting cells in the utricle and all the …

… mice [55, 56]. Therefore, injections onto, but not through, the RWM may be the least traumatic
alternative delivery … vectors are limited by technological factors that affect safety, target cell …

… consists of the membranous utricle and three semicircular … of adeno-associated viral (AAV)
vectors for gene manipulation… gene therapy as gene therapy in otology may address both …

… pharmacotherapy, gene therapy, and cell therapy approaches … Adeno-associated virus
vectors were also used to deliver … Utricle injection, which also directly access the endolymph, of …

… HC differentiation and survival in normal ears. Previous work using … mice have demonstrated
that manipulation of gene … Relevant to the work presented here, the target cells are the non-…

… transduce target cells in the mature mammalian inner ear. … adult mouse inner ear is more
susceptible to surgical trauma … hair cells) were taken per utricle specimen and the number of …

… in normal and gentamicin-damaged postnatal mouse utricles [64]… Successful gene therapy
in the targeted cells results in the … adeno-associated virus vector serotype 5 (AAV-5) as a gene …

… transduce target cells in the mature mammalian inner ear. … For quanti cation of utricular
hair cell infection e ciency, two 40x … Adeno-associated virus-mediated gene delivery into the …

… of EdU in neonatal mouse cochlear and utricular cultures [Citation69… gene therapy to the
cochlea have used adeno-associated … , can also be targeted using gene therapy. This approach …

… An angiogenesis-targeting and non-viral gene delivery … Approximately 100% of supporting
cells in the utricle and all the … Adeno-associated virus vector as a platform for gene therapy …