… by modifying chromatin structure and by acetylating transcription factors. IL-1Ra, in addition
… -α-dependent manner, synovial macrophages promotes expression of adhesion molecules (…

… in the biological behaviors such as proliferation, adhesion, migration, invasion and metastasis
of tumor … It can further induce the secretion of growth factors. These growth factors induces …

… released. Mature IL-1β is a broad-acting proinflammatory cytokine that increases the recruitment
of endothelial adhesion … As a transcription factor, hypoxia-inducible factor (HIF)-1α is an …

… showing increased gene expressions of cell adhesion molecules or monocyte-attracting
chemokines, a number of factors such as the stimulus, growth factors, and collagens are thought …

… interleukin-1 (IL-1) receptor antagonist (IL1RA), as a naturally occurring receptor antagonist,
is the first discovered and can compete with IL-1 in binding to the receptor. Recent studies …

… Phase II clinical trials show promising data with anakinra, recombinant IL-1 receptor
antagonist, in patients with ST-segment–elevation acute myocardial infarction or heart failure with …

… initiated by binding to interleukin-1 receptor (IL-1R) type 1 (IL-… and activates the transforming
growth factor β-activated … , attract adhesive factors, and release various inflammatory …

… migration inhibitory factor (rhMIF) and recombinant human interleukin-1 receptor antagonist
(rh … upstream growth factors in HCC, such as endothelial growth factor, vascular endothelial …

… focal adhesions upregulates interleukin-1 receptors on the … Among the multitude of pro-inflammatory
growth factors … This legendary growth factor has been implicated in numerous …

… NF-κB transcription factor is rescued and translocated to the nucleus. Alternatively, TAK1 …
of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1)…