… lines bearing different PTEN status, and we found constitutive … of STAT5 activity. Thus, we
investigated BCL2 expression in … Moreover, our results show that PTEN-mutated T-ALLs do not …

… Constitutive deletion of Pax5 in mice failed to produce … via PTEN inhibition to stimulate follicular
B cell proliferation (22). … constitutively active kinase activity, to drive leukemogenesis (63). …

… , we are displaying the site without styles and JavaScript. … IKAROS activity as a repressor of
MTOR, resulting in reduced … that CK2 directly inactivates PTEN through phosphorylation [5, 37…

… in leukemogenesis in ETV6-RUNX1 + B-cell ALL. Also, we … Because some of the tumors
displayed low or absent PTEN … LoxP-flanked TpA stop signals prevented constitutive IL7R gene …

… protein constitutive activation have been referred to the activity … deletion, downstream PTEN,
abrogates the activity of a highly … As observed in B-cell ALL, an amount of evidence indicate …

… , especially T-cell acute lymphoblastic leukemia (T-ALL). … that PTEN is essential for B-cell
homeostasis, including B-cell … PTEN mutation or constitutive activation of its downstream PI3K/…

… Differently from B-cell precursors ALL, where highly effective … in 8% of cases, leading to
constitutive kinase activity (84). The … NOTCH1/FBXW7 genes plus mutations in PTEN or N/K-RAS …

… transforming oncogenes in B-cell acute lymphoblastic leukaemia (B-… However, loss of the
tumour suppressor PTEN (resulting in … Inducible expression of a constitutively active mutant of …

… T-lineage acute lymphoblastic leukemia (T-ALL) is an … domain and exhibit constitutive
transcriptional activity. The … the full-length cellular Myb is also sufficient to drive spontaneous B-cell …

… We examined 28 precursor-B-cell ALL and 6 T-cell primary … PI3K/Akt are constitutively
activated in adult ALL, indicating a … relation to the PTEN gene changes, showing that mutations …