Optimizing aerosol delivery of antibiotics in ventilated patients

S Ehrmann, CE Luyt - Current Opinion in Infectious Diseases, 2020 - journals.lww.com
… is as an adjunctive therapy, that is, in addition to intravenous antibiotics to treat susceptible
bacteria. The hypothesis is that aerosolized antibiotic therapy directly targeting the lungs, …

[HTML][HTML] Aerosolized antibiotics to manage ventilator-associated infections: a comprehensive review

P Myrianthefs, GE Zakynthinos, V Tsolaki, D Makris - Antibiotics, 2023 - mdpi.com
aerosolized avert the potential evolution to VAP? Results: There were identified eight studies
that provided data on the use of aerosolized antibiotics … treated with aerosolized antibiotics. …

[HTML][HTML] Aerosolized antibiotics in the treatment of hospital-acquired pneumonia/ventilator-associated pneumonia

YJ Jung, EJ Kim, YH Choi - The Korean Journal of Internal …, 2022 - ncbi.nlm.nih.gov
… However, the rationale for the use of aerosolized antibiotics is … evidence, the use of aerosolized
antibiotics is considered as an … and side effects of aerosolized antibiotics as well as the …

Characterization of a new aerosol antibiotic/adjuvant combination for the treatment of P. aeruginosa lung infections

H Douafer, V Andrieu, E Wafo, JM Brunel - International Journal of …, 2020 - Elsevier
… On the other hand, since aerosol therapy allows a rapid … /antibiotic combination in an
aerosolized form and demonstrated the feasibility of such an approach. Thus, combination aerosol

Aerosolised antibiotics in critical care

J Rello, A Bouglé, JJ Rouby - Intensive Care Medicine, 2023 - Springer
Aerosol delivery of antibiotics to the lung parenchyma is much more difficult. Infected alveoli
(in light brown) are far from the endotracheal tube and aerosolized … of aerosol antibiotic in …

Inhaled antibiotics in critical care: State of the art and future perspectives

P Szychowiak, M Desgrouas, S Ehrmann - Infectious Diseases Now, 2022 - Elsevier
… In critically ill patients, some studies have documented the benefits of aerosolized
antibiotic therapy compared to intravenous treatment. Prophylactic administration of inhaled …

[HTML][HTML] How to use nebulized antibiotics in severe respiratory infections

J Gorham, FS Taccone, M Hites - Antibiotics, 2023 - mdpi.com
… high local concentrations of antibiotics, well above the MIC of the causative pathogens.
Unlike the systemic administration of antibiotics, aerosolized antibiotics avoid the need for drug …

Benefits of Aerosolized Phages for the Treatment of Pneumonia Due to Methicillin-Resistant Staphylococcus aureus: An Experimental Study in Rats

J Prazak, LG Valente, M Iten, L Federer… - The journal of …, 2022 - academic.oup.com
antibiotic resistance [9, 10]. Proof-of-concept experimental studies investigating aerosolized
… aeruginosa VAP treated with IV and aerosolized phages revealed positive outcomes [13]. In …

Nebulized antibiotics for ventilator-associated pneumonia: methodological framework for future multicenter randomized controlled trials

A Monsel, A Torres, Y Zhu, J Pugin… - Current opinion in …, 2021 - journals.lww.com
… Following nebulization, the tracheobronchial tree is coated with aerosolized antibiotic. The
fiberscope is contaminated during its passage and the ELF antibiotic concentrations reflect …

Scope and limitations on aerosol drug delivery for the treatment of infectious respiratory diseases

H Douafer, V Andrieu, JM Brunel - Journal of Controlled Release, 2020 - Elsevier
… development of new methods for antibiotics delivery to patients with … Since bacterial resistance
is often related to antibiotic … In conclusion, aerosol antibiotic delivery appears as one of …