… of antigen access into secondary lymphoid organs, antigen … of B cell anergy that have
significantly lower Ig-Tg affinity to self-… signals and T cell help, another factor that determines B cell …

… event resulting from an activating signal cascade. Here, we … of B-cell activation, even if
matched for the antigen affinity of … displayed by FDCs, germinal centre B cells seem to detect the …

… critical to measure memory B cell pools in addition to antibody titers. … of antibodies with higher
binding affinities for their cognate … Given the need for strong BCR signaling to initiate B cell …

… BCR signaling and their dysregulation contributing to B cell … -mediated antigen internalization
and processing determines … high-affinity antigen induces B cell permeabilization and …

… Cell fate decisions during early B cell activation determine … and expansion of B cell clones
with the highest affinity. These … of high-affinity BCRs and the abundance of signals associated …

… major routes for memory B cell and high-affinity long-lived plasma … Recent research has
aimed to determine whether BCR affinity has … They found that an affinity-based CD40 signal was …

… in GCs, antigen-binding and downstream signaling of the … may influence B cell survival or
fate specification during affinity … Second, we identify a transcriptionally distinct and clonally …

… B cell precursor frequency, B cell receptor affinity for antigen, … B cells with higher p:MHC
receive more T FH help signals … frequency, affinity, and avidity in determining B cell outcomes (…

… developing B cell recognize self-antigens with low affinity, … of BCR expression and BCR
signaling. In principle, receptor … antigen specificity of the B cell receptor determines the B cell …

… We find that maximal ASC induction requires at least eight cell … signals. In addition, we define
a path to ASC that reveal an … , and selection pressure for high affinity clones 43,44 . Using …