Metabolic determinants of Alzheimer's disease: A focus on thermoregulation

M Tournissac, M Leclerc, J Valentin-Escalera… - Ageing Research …, 2021 - Elsevier
Alzheimers disease (AD) is a complex age-related neurodegenerative … and maintenance
of body temperature. In recent years, the modulation of BAT activity has been increasingly …

[HTML][HTML] Changes in 24 h rhythmicity of spontaneous locomotor activity in the triple transgenic mouse for Alzheimer's disease (3xTg-AD) in a jet lag protocol …

…, E Arnold, S Díaz-Cintra… - Journal of Circadian …, 2021 - ncbi.nlm.nih.gov
… locomotor activity, increased body temperature, and increased food intake [21]. Also, changes
in … wheel alleviated some age-related changes in the circadian system like changes in the …

[HTML][HTML] Age related changes in muscle mass and force generation in the triple transgenic (3xTgAD) mouse model of Alzheimer's disease

H Xu, S Bhaskaran, KM Piekarz, R Ranjit… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimers disease (AD) may show accelerated sarcopenia phenotypes. To investigate
whether pathological changes … of age, we used the triple transgenic mouse model of AD (…

[HTML][HTML] Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model

M Tournissac, TM Vu, N Vrabic, C Hozer… - Alzheimer's Research & …, 2021 - Springer
… , with frequent age-related comorbidities, multi-… the triple transgenic (3xTg-AD) mice [8,9,10,11].
Studies in mouse and hibernators repeatedly showed that decreased body temperature

Disruption of metabolic, sleep, and sensorimotor functional outcomes in a female transgenic mouse model of Alzheimer's disease

DC Nwafor, S Chakraborty, S Jun, AL Brichacek… - Behavioural brain …, 2021 - Elsevier
… The objective of this study was to elucidate the extent to which metabolic activity, sleep-wake
cycle, and sensorimotor function is impaired in APPSwDI/Nos2 −/− (CVN-AD) transgenic …

[HTML][HTML] Sex-and Neuropsychiatric-Dependent Circadian Alterations in Daily Voluntary Physical Activity Engagement and Patterns in Aged 3xTg-AD Mice

D Alveal-Mellado, L Castillo-Mariqueo… - International journal of …, 2022 - mdpi.com
Alzheimers disease (AD) patients suffer from circadian rhythm alterations affecting their daily
physical activity … The triple transgenic model for AD (3xTg-AD) developed by Frank LaFerla’…

[HTML][HTML] Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer's …

CG Pontrello, JM McWhirt, CG Glabe… - … Alzheimer's Disease, 2022 - content.iospress.com
age-related decrease in Akt accompanies an increase in several neuroinflammation factors
and GSK-3β activity … We used the triple-transgenic AD mouse model from the LaFerla Lab (…

Age and gender differences for the behavioral phenotypes of 3xTg Alzheimer's disease mice

T Pairojana, S Phasuk, P Suresh, SP Huang… - Brain Research, 2021 - Elsevier
… age differences of the triple transgenic Alzheimers disease (3xTg-AD) … affects their day-to-day
activities and it is challenging to … Age-related changes in neuroactive steroid levels in 3xTg-…

Longitudinal assessment of aggression and circadian rhythms in the APPswe mouse model of Alzheimers disease

G Bergamini, H Massinet, S Durkin, MA Steiner - Physiology & Behavior, 2022 - Elsevier
… distribution of locomotor activity and core body temperature of mice in their home cages. …
aggressive behavior at 11 months, was rather an age-related behavioral change [15, 56]. …

[HTML][HTML] Age-dependent decline in synaptic mitochondrial function is exacerbated in vulnerable brain regions of female 3xTg-AD mice

…, F Bermúdez-Rattoni, S Uribe-Carvajal… - International Journal of …, 2020 - mdpi.com
… In Alzheimers disease (AD), synaptic terminal loss precedes … Furthermore, studies in isolated
mitochondria from the triple transgenicAge-related changes in oxygen consumption and …