[HTML][HTML] Alpha-synuclein aggregation in Parkinson's disease

E Srinivasan, G Chandrasekhar… - Frontiers in …, 2021 - frontiersin.org
Lewy bodies are intraneuronal inclusions that contain immunoreactive alpha-synuclein
aggregates … characteristics of Parkinson's disease, multiple system atrophy and dementia with …

Alpha-synuclein levels in the differential diagnosis of Lewy bodies dementia and other neurodegenerative disorders: a meta-analysis

I Mavroudis, F Petridis… - … Associated Disorders, 2020 - journals.lww.com
… of Lewy bodies and Lewy neurites which are composed of aggregated phosphorylated
alpha-synuclein, … genetically and neuropathologically linked to Parkinson disease and to LBD. …

[HTML][HTML] Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports

HA Lashuel - Neurobiology of disease, 2020 - Elsevier
… a comparative review of DLB and Parkinson's disease dementia (PDD) by Jellinger … ie, Lewy
bodies—to describe all the different forms of aSyn pathologies in the brain. The aggregation

[HTML][HTML] Expression levels of an alpha-synuclein transcript in blood may distinguish between early dementia with lewy bodies and parkinson's disease

L Marsal-García, A Urbizu, L Arnaldo… - International journal of …, 2021 - mdpi.com
bodies (DLB) and Parkinson disease (PD) are characterized by … LBP consists of abnormal
intraneuronal aggregates of alpha-synuclein (AS), so called Lewy bodies (LBs), and Lewy

[HTML][HTML] Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson's disease and dementia with Lewy bodies

K Brockmann, C Quadalti, S Lerche, M Rossi… - Acta neuropathologica …, 2021 - Springer
… with Parkinson's disease (PD) and dementia with Lewy bodies (… minute amounts of
disease-specific protein aggregates in CSF … 83–98% specificity for sporadic LBD such as PD and …

[HTML][HTML] Alpha-synuclein post-translational modifications: implications for pathogenesis of lewy body disorders

NO Manzanza, L Sedlackova… - Frontiers in aging …, 2021 - frontiersin.org
… as Lewy Bodies (LBs) and extracellular Lewy Neurites (LNs). … predominantly comprise
aggregates of alpha-synuclein (aSyn… dementia with Lewy Bodies (DLB), Parkinson's disease (PD), …

[HTML][HTML] Alpha-synuclein aggregation pathway in Parkinson's disease: current status and novel therapeutic approaches

M Vidović, MG Rikalovic - Cells, 2022 - mdpi.com
… protein/peptide aggregation into insoluble, amyloid fibrils [6]. Intracellular protein aggregates
mostly composed of α-Syn found in Lewy bodies (LBs) or enlarged neurites (Lewy neurites, …

[HTML][HTML] Lewy body-associated proteins A-synuclein (a-syn) as a plasma-based biomarker for Parkinson's disease

X Zhao, H He, X Xiong, Q Ye, F Feng, S Zhou… - Frontiers in Aging …, 2022 - frontiersin.org
… (PD) is mainly characterized by pathological aggregation of … PD and the atypical parkinsonian
disorders turns out to be … Regarding PD dementia severity, we tested the relationship …

[HTML][HTML] Distinct tau and alpha-synuclein molecular signatures in Alzheimer's disease with and without Lewy bodies and Parkinson's disease with dementia

BL van der Gaag, NAC Deshayes, JJP Breve… - Acta …, 2024 - Springer
bodies (LBs) and Lewy neurites (LNs), consisting of damaged organelles, lipids and aggregated
alpha-synuclein … , they act as a template for aggregation of physiological soluble protein …

[HTML][HTML] Alpha-synuclein in Parkinson's disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction

P Calabresi, A Mechelli, G Natale… - … death & disease, 2023 - nature.com
… neurodegenerative disorders such as dementia with Lewy bodies, … aggregates of α-syn,
such as Lewy bodies (LB) and Lewy … in several sporadic neurodegenerative diseases termed α-…