… and compare the bronchial bacterial load related to cell … in bronchial biopsies of stable COPD
patients with rapid vs slow vs no … We defined rapid decline as rate of FEV1 decline >70 ml/…

… cohort follow-up, and we did not quantify bacterial load but used instead a cut-off point of …
Airway bacterial load and FEV 1 decline in patients with chronic obstructive pulmonary disease…

… Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease (…
UK centers, that baseline airway dysbiosis in COPD patients, characterized by the enrichment …

… Data on bacterial load in positive cultures were sparingly … FEV1 data were reported across
most studies as mean FEV1 (… in airways disease, such as aspergillus, are not bacteria and …

… volume in 1 s (FEV1) only. This … of airway bacteria occurring during acute exacerbations
of COPD [10,11,12]. An increased bacterial load has been associated with a decline in lung …

… of bacteria and the microbiota composition in COPD airways … the airways’ bacterial load and
the bronchial inflammation has … in COPD patients’ airways further contributes to reduction of …

… concentration in the bronchial tree, decreasing the bacterial load in the airways and favoring
… Mean FEV1(%) = 43% Reduction in total numbers of sputum cells and neutrophil elastase. …

… by bacterial colonization [5,11-13]. Stable chronic obstruction patients showing more airway
… is a significant decline in the lung volumes studied FEV1, FVC, and FEV1% of the COPD …

… of airway inflammatory mediators are significantly associated with a faster decline in forced
expiratory volume in 1 s (FEV1), … profile is related with a high bacterial burden [28] and emphy…

… bacterial richness and diversity in stool samples changed significantly when the FEV 1 declined
more than 40 ml/year (decline … control (Bacteroidetes) and decline (Firmicutes) groups. …