… of testicular function and the disruption of spermatogenesis [9,10]. … altered ATP production
[56]. Inhibition of AMPK-mediated phosphorylation of TSC2 activates mTOR signaling pathway …

… Besides, in mature Sertoli cells, this pathway can disintegrate the structure of the blood-testis …
Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of sertoli cell polarity …

… show defects in Sertoli cell polarity and testicular junctional … It is well known that the
maintenance of Sertoli cell polarity … AICAR treated embryos displayed altered blastocyst formation …

… sperm number and quality and altered hormonal concentrations. … spermatogenesis by
disrupting the function of Sertoli cell junctions… proteins and in spermatid polarity, we examined the …

… This study unveiled that TP exposure altered the localization of the TJ protein ZO-1, as
well as the basal ES proteins N-Cadherin and β-Catenin. These proteins are not densely …

… Sertoli cells (SCs) are very important in regulating spermatogenesis by secreting growth …
supports to promote the development and movement of germ cells (Hai et al. 2014). Blood-testis …

… signaling pathway in Sertoli cells impaired organization of the seminiferous epithelium and
loss of Sertoli cell polarity, which eventually caused … mTORC1 inhibition or disruption on male …

… mTOR protein level was not changed between these two cell … What’s more, gene disruption
of S6K1 in mice does not cause … focusing on the Sertoli cell and germ cell interaction. Loss of …

… required in both stromal and Sertoli cells for the occurrence of LCCSCTs. … In order to assess
the role of WNT4 in GC-altered … In this study, mTOR pathway activation induced by disruption …

… is required in both stromal and Sertoli cells for the occurrence of LCCSCT. … In order to assess
the role of WNT4 in GC altered … pathway activation induced by disruption of the LKB1/AMPK …