[HTML][HTML] Opposite regulation of glycogen metabolism by cAMP produced in the cytosol and at the plasma membrane

PFV Bizerra, EH Gilglioni, HL Li, S Go… - … et Biophysica Acta (BBA …, 2024 - Elsevier
… The cAMP standards for the competitive ELISA were prepared in a modified assay diluent
(… Immunoblotting showed that HepG2 cells expressed a 75 kD sAC isoform, which was …

Roles of Phosphorylation of N-Methyl-d-Aspartate Receptor in Chronic Pain

L Pan, T Li, R Wang, W Deng, H Pu, M Deng - Cellular and Molecular …, 2023 - Springer
… and differentially affect the subcellular distribution of GluN1. … density—95, disks—large,
and zonula occludens—1)-binding … Then, the phosphorylated CREB combines with the cAMP

GPCRs in intracellular compartments: New targets for drug discovery

I Fasciani, M Carli, F Petragnano, F Colaianni, G Aloisi… - Biomolecules, 2022 - mdpi.com
… for the calcium sensing receptor [75], the secretin receptor [76]… signaling in real time without
altering the cell homeostasis. … [26] examined the subcellular distribution of the activated β2 …

Modulation of D3R Splicing, Signaling, and Expression by D1R through PKA→PTB Phosphorylation

…, G Tovar-Medina, CD Florán-Hernández… - Biomedicines, 2024 - mdpi.com
… was washed two times with 1 mL of 75% ethanol. The … the stimulation of cAMP accumulation
via D 1 R and D 1 R+D … D 1 R regulating D 3 R splicing and function, which is altered

… sleep quality-and myopia-linked PDE11A-Y727C variant impacts neural physiology by reducing catalytic activity and altering subcellular compartmentalization of the …

I Sbornova, E van der Sande, S Milosavljevic… - Cells, 2023 - mdpi.com
… role that the PDE11 substrates cAMP and cGMP play in eye … and distinctive subcellular
distributions [1]. Thus, each PDE … We computed the mean and standard deviation from the 25–75

The relevance of amyloid β-calmodulin complexation in neurons and brain degeneration in Alzheimer's disease

J Poejo, J Salazar, AM Mata… - International Journal of …, 2021 - mdpi.com
… Aβ(1–42) with CaM did not significantly alter calcium binding … calcium trapping kinetics,
subcellular distribution, and affinity … phosphodiesterase isoforms modulate intracellular cAMP

Integrin-linked kinase (ILK): the known vs. the unknown and perspectives

A Górska, AJ Mazur - Cellular and Molecular Life Sciences, 2022 - Springer
… domain, and kinase domain (KD). B Cartoon representation … , which were next merged and
modified in Swiss-PdbViewer (… by PAK1 in its functions [75]. An essential role in the negative …

[PDF][PDF] CAMSAP2 localizes to the Golgi in islet β-cells and facilitates Golgi-ER trafficking

KH Ho, A Jayathilake, Y Mahircan, A Nour… - Iscience, 2023 - cell.com
… We propose that a novel CAMSAP2 isoform in primary b-cells … to cAMP and Ca2+ in
CAMSAP2-KD cells. We stimulated … , CAMSAP2-KD in primary b-cells does not alter microtubule …

LIM-kinases in synaptic plasticity, memory, and brain diseases

Y Ben Zablah, H Zhang, R Gugustea, Z Jia - Cells, 2021 - mdpi.com
… found in various shapes and can alter their morphology during … to be regulated by cofilin
phosphorylation [75,76]. Spine … (1) Is the subcellular distribution of LIMK1 regulated by synaptic …

A general concept of quantitative abiotic stress sensing

KJ Dietz, L Vogelsang - Trends in Plant Science, 2023 - cell.com
… (B) Effect of altering KD to ten-times-lower or -higher values. (C) … receptor activates adenylate
cyclase that generates cAMP. … Fine-tuning of RBOH isoform activity allows cells to tailor O2 …