A general concept of quantitative abiotic stress sensing

KJ Dietz, L Vogelsang - Trends in Plant Science, 2023 - cell.com
… (B) Effect of altering KD to ten-times-lower or -higher values. (C) … receptor activates adenylate
cyclase that generates cAMP. … Fine-tuning of RBOH isoform activity allows cells to tailor O2 …

CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
… of membrane proteins (74, 75). The opposing argument was … % reduced cardiac CPT-1
activity but failed to alter the rates of … this is the main Akt isoform involved in CD36 translocation (…

LIM-kinases in synaptic plasticity, memory, and brain diseases

Y Ben Zablah, H Zhang, R Gugustea, Z Jia - Cells, 2021 - mdpi.com
… found in various shapes and can alter their morphology during … to be regulated by cofilin
phosphorylation [75,76]. Spine … (1) Is the subcellular distribution of LIMK1 regulated by synaptic …

Emerging roles of calcium signaling in the development of non-alcoholic fatty liver disease

CC Chen, LW Hsu, KD Chen, KW Chiu… - International journal of …, 2021 - mdpi.com
… Increased cAMP further leads to the activation of protein kinase … show more functional
specificity in various cell types [75]. … These changes can further alter the systemic energy …

Cardiac cAMP-PKA signaling compartmentalization in myocardial infarction

AS Colombe, G Pidoux - Cells, 2021 - mdpi.com
… (Gα s ) stimulates all AC isoforms to produce cAMP, while Gα i/… 60% of intracellular cAMP
production, respectively [73,75]. … in cardiac physiology and are extensively modified post-MI. …

cAMP-dependent signaling and ovarian cancer

A Kilanowska, A Ziółkowska, P Stasiak, M Gibas-Dorna - Cells, 2022 - mdpi.com
… , MAPK, and the 90 kD ribosomal S6 kinase of various serine … with some intracellular effectors
[75]. Both receptors belong … of a tumor to identify altered genes and pathways that enable …

Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts

PY Ng, ABP Ribet, Q Guo, BH Mullin, JWY Tan… - Nature …, 2023 - nature.com
… Next, we examined the subcellular distribution of endogenous … the subcellular distribution
of the two Slc37a2 isoforms in … in Slc37a2 KO SLs altered their capacity to translocate to the …

Brain energy metabolism: A roadmap for future research

CD Rae, JA Baur, K Borges, G Dienel… - Journal of …, 2024 - Wiley Online Library
… Both neurometabolic and neurovascular coupling are altered in a … What is the mitochondrial
subcellular localization of the … By regulating the formation of cAMP via the lactate receptor …

Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?

AK Samhan-Arias, J Poejo, D Marques-da-Silva… - Molecules, 2023 - mdpi.com
… present a differential subcellular distribution within a single … Cav-1–knocking down (Cav-1KD)
and the disruption of Cav-1-… ’s disease where an alteration of signaling processes …

Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities

A Samidurai, L Xi, A Das, AN Iness… - Pharmacology & …, 2021 - Elsevier
… specific and isoforms such as PDE 4,7 and 8 solely hydrolyze cAMP molecules … 1,2,3,10
and 11 are family of enzymes that are dual substrate specific and can hydrolyze both cAMP