[HTML][HTML] Acid-sensing ion channel 1: potential therapeutic target for tumor

Y Wang, H Zhou, Y Sun, Y Huang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
… hybrid channel is responsible for the amiloride-sensitive current that is seen in human glioma
cells [… -bound ion channels play a key role in regulating many signaling pathways in tumor …

Pharmacological inhibition of membrane signaling mechanisms reduces the invasiveness of U87-MG and U251-MG glioblastoma cells in vitro

A Varricchio, S Khan, ZK Price, RA Davis, SA Ramesh… - Cancers, 2023 - mdpi.com
Human glioblastoma cell lines U87-MG and U251-MG (… CKD4 and mutation of transcriptional
regulator ATRX [83] in U87-… of the amiloride-sensitive acid-sensing ion channel 1 (ASIC1) […

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention

Z Zhang, M Chen, W Zhan, Y Chen, T Wang… - Cell Death …, 2023 - nature.com
improves its binding to C/EBP in the process of insulin deficiency-induced nerve cell apoptosis,
lowering the negative regulatoryamiloride-sensitive cations into advanced glioma cells […

Recent advances in acid-sensitive ion channels in central nervous system diseases

Y Zhu, X Hu, L Wang, J Zhang, X Pan… - Current …, 2022 - ingentaconnect.com
… epithelial sodium channel subunits in human glioma cells … association between the
Amiloride-Sensitive Cation Channel 2 (… Regulation of ASIC1 by Ca2+/ calmodulin-dependent …

An update regarding the role of WNK kinases in cancer

M Xiu, L Li, Y Li, Y Gao - Cell Death & Disease, 2022 - nature.com
… , including the amiloride-sensitive epithelial sodium channel (… or γ-ENaC in human gliomas
is wildly found to promote … thereby inducing regulatory volume increase (RVI) in glioma cells […

Mambalgin-2 inhibits lung adenocarcinoma growth and migration by selective interaction with ASIC1/α-ENaC/γ-ENaC heterotrimer

AV Sudarikova, ML Bychkov, DS Kulbatskii… - Frontiers in …, 2022 - frontiersin.org
… Different types of ion channels are involved in the regulation … -sensing ion channels (ASICs)
contribute to cellular response to … of the amiloride-sensitive ASIC1a-containing channels by …

The 32nd Ion Channels Meeting, 17th–20th September 2023, Sète, France

F Brette, AR Cantelmo, V Coronas, M Demion… - Bioelectricity, 2024 - liebertpub.com
… as mutant SOD1, contribute to the increased surface trafficking of … that the volume increase
activates the regulatory volume … the electrogenic and amiloride-sensitive sodium retention in …

Salt sensation and regulation

S Puri, Y Lee - Metabolites, 2021 - mdpi.com
… , including neuronal activity, fluid volume, acid–base balance, … the amiloride-sensitive
degenerin/epithelial Na + channels (… intake may contribute to cell and organ growth, tumorigenesis…

DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Man

L Bianchi - Ion Channels in Biophysics and Physiology, 2022 - Springer
… This channel increases the excitability of snail neurons when … and recorded amiloride-sensitive
sodium conductance in … of regulation of neuronal output by these channels might be …

Aggressive migration in acidic pH of a glioblastoma cancer stem cell line in vitro is independent of ASIC and KCa3.1 ion channels, but involves phosphoinositide 3 …

KD Cortés Franco, IC Brakmann, M Feoktistova… - … -European Journal of …, 2023 - Springer
… Using a 2.5D migration assay, here we report that acidic pH dramatically increased … +
channel (also known as IKCa) activated by intracellular Ca 2+ . It contributes to controlling the cell