… therapeutics (eg, digoxin, amiodarone, aspirin) were developed when the technology to
identify specific molecular targets was not available. Some drugs (eg, amiodarone) have many …

… should be informed that the patient is taking amiodarone; … (verapamil, diltiazem), stimulant
laxative agents which may … , torsades de pointes with increased quinidine and disopyramide; …

… Lidocaine and quinidine, a Class Ib and Class Ia sodium … nor the Class III antiarrhythmic
amiodarone were found to affect … reported on the beneficial effects of digoxin therapy in patients …

… inhibited by typical ABCB1 inhibitors such as verapamil, cyclosporin … ABCB1 substrates
(quinidine, prazosin, fexofenadine, digoxin, and … As shown in Table 1, fluconazole, amiodarone, …

… underlying condition, like digitalis toxicity, postcardiac … G Quinidine Quinidine depresses the
rapid inward depolarizing … mechanisms and pharmacological effects Amiodarone is usually …

… may include an increase in the frequency or severity of the side effects but generally would
not require a … B inducing hypokalaemia may cause arrhythmia and potentiate digitalis toxicity. …

… is very important for reducing thrombo-embolic events [47]. For the control of heart rate, the
use of digoxin, beta-blockers or verapamil/diltiazem is … Dabigatran Amiodarone High plasma …

… such as itraconazole, verapamil, and clarithromycin have been … studies with digoxin are
conducted for new drugs that are P-… of quinidine has only a minimal additive effect on codeine PK …

… necessary in renal impairment and with concurrent use of drugs that displace digoxin from
its binding sites or reduce its renal excretion, such as verapamil, quinidine and amiodarone. …

… non- dihydropyridine calcium antagonists, namely verapamil … include intravenous digoxin
or intravenous amiodarone, … , amiodarone, and quinidine, can alter digoxin pharmacokinetics. …