… What is more, digoxin plus dofetilide and amiodarone plus … , which is an infusion of
isoproterenol, verapamil, or quinidine … We can also consider the chronic use of quinidine to …

… of the toxinreceptor from its binding site. Currently, antibody … of digoxin poisoning and snake
venom, but it is not … activity (eg, verapamil, diltiazem, amiodarone, and other arrhythmic drugs…

… was synthesized in 1934 by Bayer and surged as an efficient replacement for natural
quinine… The use of amiodarone increases its plasmatic concentrations and increases the risk of …

… is especially important to insure that a therapeutic effect observed in a preclinical species is
not due to an active metabolite that is not … Soft electrophiles are uncharged (quinine methide …

… , and spironolactone may alter the clearance of digitalis glycosides. … effect of digoxin and
the negative isotropic effects of antiarrhythmic agents, such as disopyramide and quinidine, are …

… Relative: Prinzmetal’s angina (unopposed α-spasm), high doses of other agents depressing
SA or AV nodes (verapamil, diltiazem, digoxin, antiarrhythmic agents); in angina, avoid …

… , a greater impact on drug absorption will be observed with high oral doses. For example,
the antifungal drug griseofulvin and the cardiac glycoside drug digoxin are both poorly water-…

… Some drugs that are not proarrhythmic, such as verapamil (… this is verapamil, a potent
hERG blocker that does not cause … Amiodarone is an example of a drug that affects multiple …

… , whereas the clinical effects of digoxin, ACE inhibitors, or β-blockers may require weeks or
… , amiodarone, and nondihydropyridine CCBs, such as diltiazem and verapamil. While some …

… Clinically relevant DDIs with dabigatran occur with strong inhibitors or inducers of P-gp
such as verapamil, digoxin, quinidine, dronedarone, and amiodarone as they may significantly …