Landscape of preterm birth therapeutics and a path forward

BS Coler, O Shynlova, A Boros-Rausch, S Lye… - Journal of Clinical …, 2021 - mdpi.com
… -spectrum antibiotics might prolong pregnancy and prevent … Preterm premature rupture of
membranes (PPROM) is a … of OBE-022 found favorable pharmacokinetic characteristics and no …

Repurposing existing drugs as a therapeutic approach for the prevention of preterm birth

BM Arman, NK Binder, N de Alwis… - …, 2023 - rep.bioscientifica.com
Spontaneous preterm labour is often idiopathic but can be associated with intra-amniotic
infection (treated with antibiotics) or … Preterm labour is managed by tocolysis to provide time to …

Intra-Amniotic Infection with Ureaplasma parvum Causes Preterm Birth and Neonatal Mortality That Are Prevented by Treatment with Clarithromycin

K Motomura, R Romero, Y Xu, KR Theis, J Galaz… - MBio, 2020 - Am Soc Microbiol
… that the administration of antibiotics improves perinatal outcomes in women with intra-… Three
antibiotics were administered in these studies to achieve broad coverage, but among these …

Adverse paediatric outcomes of macrolide antibiotics treatment in pregnancy

H Fan - 2020 - discovery.ucl.ac.uk
… for an association between macrolide antibiotics use during early pregnancy and an increased
… of macrolides in pregnancy and recommendation of alternative antibiotics where feasible. …

Skin testing and oral amoxicillin challenge in the outpatient allergy and clinical immunology clinic in pregnant women with penicillin allergy

MM Kuder, MG Lennox, M Li, DM Lang… - Annals of Allergy, Asthma & …, 2020 - Elsevier
… We conducted a retrospective review of all pregnant women … The patients underwent oral
amoxicillin challenges based on … Pregnant women with premature rupture of membranes are …

Antenatal dexamethasone for late preterm birth: a multi-centre, two-arm, parallel, double-blind, placebo-controlled, randomized trial

WHO Action Trials Collaborators - EClinicalMedicine, 2022 - thelancet.com
… in a liveborn neonate; and possible maternal bacterial infection (occurrence of maternal fever
≥ 38 C or clinically suspected or confirmed infection for which therapeutic antibiotics were …

Clinical utility of a model‐based amoxicillin dosage regimen in neonates with early‐onset sepsis

C Kou, DF Li, BH Tang, L Dong, BF Yao… - British journal of …, 2022 - Wiley Online Library
… has been empirically used to treat neonates with early-onset sepsis (EOS). Population
pharmacokinetics of amoxicillin in neonates and young … -premature rupture of membranes 18 …

[引用][C] The use and safety of antibiotic therapy in pregnant women.

S Naidoo - 2020

Clinical pharmacokinetics and pharmacodynamics of anti-tubercular drugs in pregnancy

JR Shiu, A Min, TKL Kiang - … of Drug Metabolism and Pharmacokinetics, 2021 - Springer
… Similarly, the pharmacokinetic data of anti-TB agents were … that pregnancy has an extensive
impact on the pharmacokinetics … to predict pregnancy-associated pharmacokinetic changes …

Considerations for Treating Nonobstetric Diseases in Pregnant Patients in the Emergency Department Setting

LS Eiland, JB Harris… - Annals of …, 2023 - journals.sagepub.com
… and pharmacokinetic changes that occur in pregnancy can … Acute pain is a commonly
treated condition during pregnancy… taken during pregnancy behind antiemetics and antibiotics. …