Induced Pluripotent Stem Cells: Progress toward Clinical Translation from Bench to Bedside

AOJ Fakoya, AE Omole, N Satyadev… - … of stem cell therapy, 2022 - Springer
… -based drug repurposing for amyotrophic lateral sclerosis medicine (iDReAM) study: protocol
for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients. …

Nanovesicular-mediated intranasal drug therapy for neurodegenerative disease

S Singh, R Shukla - AAPS PharmSciTech, 2023 - Springer
… Numerous neurodegenerative conditions, such as Alzheimer’s, Huntington’s, Parkinson’s,
amyotrophic lateral sclerosis, and glioblastoma multiform are now becoming significant …

A Sex-dependent Response to dl-PHPB in an Amyotrophic Lateral Sclerosis Disease Mouse Model

U MacKenzie - 2021 - dalspace.library.dal.ca
… There are currently only two FDA approved drugs for its treatment, and both offer mild …
treatment. dl-Potassium 2-(1-Hydroxypentyl)-benzoate (dlPHPB) is a novel drug for the treatment

Trauma and amyotrophic lateral sclerosis: a systematic review and meta-analysis

D Gu, S Ou, M Tang, Z Yin, Z Wang… - Amyotrophic Lateral …, 2021 - Taylor & Francis
… trauma is considered a potential risk factor of amyotrophic lateral sclerosis (ALS), but their
… targeted treatment regimens and make prophylactic strategies for ALS in traumatic patients. …

Identification of a novel therapeutic target in vascular dysfunction: a showcase of reverse and forward translational research linking bench to bedside

H Iwata, T Minamino - European Heart Journal, 2022 - academic.oup.com
… and also a clinically available medication for patients with liver … diseases, including amyotrophic
lateral sclerosis (ALS). … a potential therapeutic candidate for ALS because of its multiple

Short TDP-43 Isoforms as Therapeutic Targets and Biomarkers for Amyotrophic Lateral Sclerosis

V Belzil, S Barmada, P Valdmanis… - 2022 - apps.dtic.mil
therapy approach with the potential to impact the large majority of ALS patients, and to be
quickly translated from bench to bedside. … Once the optimal dosing and length of treatment has …

[HTML][HTML] Identification of a novel pathway in sporadic Amyotrophic Lateral Sclerosis mediated by the long non-coding RNA ZEB1-AS1

F Rey, E Maghraby, L Messa, L Esposito… - Neurobiology of …, 2023 - Elsevier
… the pathogenesis of sporadic Amyotrophic Lateral Sclerosis (sALS) is … Amyotrophic Lateral
Sclerosis (ALS) is a progressive … primary therapy for ALS with a very limited number of drugs

Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
… This review provides a comprehensive analysis of the potential of antioxidant therapy,
challenges in their clinical translation, and the role nanoparticles/drug delivery systems could play …

Diabetes mellitus and amyotrophic lateral sclerosis: a systematic review

L Ferri, P Ajdinaj, MG Rispoli, C Carrarini, F Barbone… - Biomolecules, 2021 - mdpi.com
Background: Amyotrophic Lateral Sclerosis (ALS) is a degenerative disorder which affects
the motor neurons. Growing evidence suggests that ALS may impact the metabolic system, …

Peripheral extracellular vesicles in neurodegeneration: pathogenic influencers and therapeutic vehicles

X Liu, L Shen, M Wan, H Xie, Z Wang - Journal of Nanobiotechnology, 2024 - Springer
amyotrophic lateral sclerosis epitomize a class of insidious and relentless neurological
conditions that are difficult to cure. Conventional therapeutic … in the pharmacological treatment of …