… pathways in spinal cord motor neurons in ALS patients. The identification of switch genes may
unveil previously unknown mechanisms … the discovery of potential new treatments. Future …

… disease with the progressive loss of motor neurons, leading to … of the disease, and find new
targets for the treatment of ALS. … , causing sensory neuron disorders and sensory symptoms. …

… ’s disease in France, and motor neuron disease in the UK. … , and there are many pathogenic
mechanisms that may affect the … , the FDA granted investigational new drug trial approval for …

… and neural stem cells as possible treatment for ALS. … a degeneration of upper and lower
motor neurons. A hallmark of … In this paper the pathological mechanisms relevant to ALS and …

… molecular mechanisms involved in these pathologies, such as excitotoxicity, mitochondrial
… structural changes in the visual pathway in ALS patients. New techniques such as OCT have …

… When motor neurons (MNs) become dysfunctional or die, … alternative mechanisms and
limiting the emergence of new … been implicated in several neuronal diseases, including ALS […

… and related subtypes of motor neuron disease, to reduce the … regardless of the underlying
cause or disease mechanisms … an add-on therapy to riluzole suggested a positive effect on …

… neuron disease, is a devastating neurodegenerative … We review new insights into the
pathophysiology of ALS which … key pathogenic mechanisms relevant to all motor neuron cellular …

… fatal neurodegenerative disease that affects motor neurons (… Many molecular mechanisms
have been suggested, … therapeutic strategies that have been suggested for ALS management. …

… be a major mechanism in ALS causing motor neuron death, … treat PD, rasagiline (Figure 5),
has been proposed to protect … misfolded proteins related to motor neuron diseases, such as …