[HTML][HTML] Sertoli cell-germ cell interactions within the niche: paracrine and juxtacrine molecular communications

MC Hofmann, E McBeath - Frontiers in Endocrinology, 2022 - frontiersin.org
… rise to more mature germ cells called A paired and A aligned spermatogonia. Collectively, A
… , the germ cells underwent apoptosis. The authors also showed that ARID4B can function as …

Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in Xkr8-Deficient Male Mice

Y Yamashita, C Suzuki, Y Uchiyama… - Molecular and cellular …, 2020 - Taylor & Francis
… (Xkr4, Xkr8, and Xkr9) that function as caspase-dependent scramblases (Citation20)… apoptotic
germ cells during first-round spermatogenesis is essential for productive spermatogenesis

Regulation of spermatogenic cell apoptosis by the pro-apoptotic proteins in the testicular tissues of mammalian and avian species

M Zakariah, RA Molele, MAA Mahdy… - Animal Reproduction …, 2022 - Elsevier
… of the pathways of germ cell apoptosis (extrinsic and intrinsic)… proteins functionally either
promote or inhibit apoptosis, and … In the early stage of apoptosis, the dense chromatin material …

Regulation of meiotic progression by Sertoli-cell androgen signaling

H Larose, T Kent, Q Ma, AN Shami… - … Biology of the Cell, 2020 - Am Soc Cell Biol
… Sertoli-cell AR signaling is required for spermatocytes to acquire … gene set may function to
license spermatocytes for progression … due to apoptosis, we analyzed germ cells at the same …

Transcriptional control of human gametogenesis

F Fang, PJ Iaquinta, N Xia, L Liu, L Diao… - Human …, 2022 - academic.oup.com
… The primordial germ cells (PGCs) arise early in development … potentially required for later
stages of PGC function and germ cell … In the XX testis, the XX germ cells enter spermatogenesis

Single-cell transcriptomic profiling of the mouse testicular germ cells reveals important role of phosphorylated GRTH/DDX25 in round spermatid differentiation and …

R Kavarthapu, R Anbazhagan, S Pal… - International Journal of …, 2023 - mdpi.com
developmental trajectory of germ cells from spermatogonia to … and apoptosis in renal, ovarian
and lung carcinoma cells [32]. … WT groups, we used the pairwise FindMarkers function of …

[HTML][HTML] Metabolic control of germline formation and differentiation in mammals

Y Hayashi, Y Matsui - Sexual Development, 2022 - karger.com
… interventions on germ cell function and epigenomic regulation is … Spermatocytes are
intermediate developing germ cells … than testicular germ cells at earlier developmental stages, and …

Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation

G Varuzhanyan, MS Ladinsky, S Yamashita… - …, 2021 - journals.biologists.com
… To address whether the large numbers of apoptotic germ cells in … S8/Fis1 mice, we first
performed PAS staining in juvenile P28 … function during spermatogenesis, we have used the male …

The role of Wnt signaling in male reproductive physiology and pathology

R Xue, W Lin, J Sun, M Watanabe, A Xu… - Molecular human …, 2021 - academic.oup.com
function to Wnt4 in spermatogenic structures, and it is reportedly necessary for sex development
in … conditionally knocked out β-catenin in early spermatogonia of mice, and no abnormal …

Post-transcriptional regulation in spermatogenesis: all RNA pathways lead to healthy sperm

M Morgan, L Kumar, Y Li, M Baptissart - Cellular and Molecular Life …, 2021 - Springer
… Multiple RNA pathways are required to produce functional … stages of spermatogenesis, from
primordial germ cells (PGC) … can trigger apoptosis; failure to induce programmed cell death