MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis

X Wang, Y Wen, J Zhang, G Swanson, S Guo… - …, 2021 - journals.biologists.com
… Interestingly, when the first wave of spermatogenesis … , most germ cells are gradually lost
from P35 by apoptosis, and the … loss-of-function of either MFN1 or MFN2 in postnatal male germ

[HTML][HTML] Three-dimensional morphological analysis of spermatogenesis in aged mouse testes

T Nakano, H Nakata, S Kadomoto, H Iwamoto… - Scientific Reports, 2021 - nature.com
… We detected region-specific morphological and functional … testis causes germ cell apoptosis
and Sertoli cell dysfunction 32,… To analyze age-related alterations in spermatogenic waves, …

Protein phosphatase 6 is a key factor regulating spermatogenesis

WL Lei, F Han, MW Hu, QX Liang, TG Meng… - Cell Death & …, 2020 - nature.com
… To investigate the function of PP6 in spermatogenesis (referred to as Ppp6c cKO ), we first
… immunofluorescence staining of the germ cell marker MVH to characterize the first wave of …

The male germline-specific protein MAPS is indispensable for pachynema progression and fertility

M Li, J Zheng, G Li, Z Lin, D Li, D Liu… - Proceedings of the …, 2021 - National Acad Sciences
germ cell death and male infertility. Finally, by detailed molecular studies, we showed that
Maps −/− spermatocytes … To determine the functional roles of MAPS in germ cells, we used the …

Single-cell RNAseq analysis of testicular germ and somatic cell development during the perinatal period

K Tan, HW Song, MF Wilkinson - Development, 2020 - journals.biologists.com
… the transient cell population that generates the ‘first wave of … germ cells were able to rescue
spermatogenesis in germ cell-… to function in and between germ and somatic cell subsets …

[HTML][HTML] Understanding the underlying molecular mechanisms of meiotic arrest during in vitro spermatogenesis in rat prepubertal testicular tissue

J Saulnier, F Chalmel, M Delessard, L Moutard… - International Journal of …, 2022 - mdpi.com
… and revealed that defective BTB function, altered steroidogenic … of spermatogenesis were
observed, with meiotic germ cells … induce the early apoptosis of pachytene spermatocytes [34]. …

[HTML][HTML] Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertility

H Bellil, F Ghieh, E Hermel, B Mandon-Pepin… - Basic and clinical …, 2021 - Springer
… of spermatogenesis requires the identification and functional … a key role in the early stages
of germ cell development. The … Tex11-deficient spermatocytes mostly undergo apoptosis at …

Proper timing of a quiescence period in precursor prospermatogonia is required for stem cell pool establishment in the male germline

G Du, MJ Oatley, NC Law, C Robbins, X Wu… - …, 2021 - journals.biologists.com
… primordial germ cells on establishment of the spermatogenic … study that showed massive
apoptosis of prospermatogonia … the first round of spermatogenesis or function as stem cells to …

[HTML][HTML] Molecular biology of spermatogenesis: novel targets of apparently idiopathic male infertility

R Cannarella, RA Condorelli, LM Mongioì… - International journal of …, 2020 - mdpi.com
… , typically involves three different functional phases occurring in … During prophase I, the
first step of meiosis, double-strand … steps of spermatogenesis, such as germ cell proliferation, …

Studying human reproductive biology through single-cell analysis and in vitro differentiation of stem cells into germ cell-like cells

L Li, R Yang, C Yin, K Kee - Human Reproduction Update, 2020 - academic.oup.com
… To validate the functional roles of these gene markers, … in aged early-stage monkey oocytes,
and increased apoptosis plus … undifferentiated spermatogonia; differentiated spermatogonia