The developmental dynamics of the human male germline

J Hargy, K Sasaki - Development, 2023 - journals.biologists.com
… Male germ cell development starts when pluripotent cells undergo … to the first wave of
spermatogenesis that generates functional … through apoptotic cell death. Notably, some M-pro-…

The foundational framework of tumors: Gametogenesis, p53, and cancer

C Liu, A Moten, Z Ma, HK Lin - Seminars in cancer biology, 2022 - Elsevier
… are often removed through programmed cell death in a p53-… restricted to immature germ cells,
such as spermatogonia and oogonia/… The function of most CT antigens is unclear since the …

[HTML][HTML] Hormone Regulation in Testicular Development and Function

L Li, W Lin, Z Wang, R Huang, H Xia, Z Li… - International Journal of …, 2024 - mdpi.com
… In the early stage of meiosis, FSH protects spermatocytes from … increased germ cell apoptosis
and disruptions in spermatogenesis [141]. The involvement of estrogen in the development

[HTML][HTML] Molecular regulation of copper homeostasis in the male gonad during the process of spermatogenesis

S Herman, P Lipiński, M Ogórek, R Starzyński… - International journal of …, 2020 - mdpi.com
… that primary spermatocytes died through apoptosis [64]. In the … in primary spermatocytes is
of key importance for germ cells at … suggest that the function of ATP7B in myoid cells might be …

[HTML][HTML] Chemotherapy induced damage to spermatogonial stem cells in prepubertal mouse in vitro impairs long-term spermatogenesis

F Lopes, P Tholeti, SK Adiga, RA Anderson… - Toxicology Reports, 2021 - Elsevier
… ex vivo spermatogenesis in prepubertal mouse testis, as first … inducing apoptosis in germ
cells, as they do in neoplastic cells [… of spermatogenesis, we evaluated key stages of germ cell

Regulation of spermatogonial stem cell self-renewal and proliferation in mammals

BH Wei, SL Hao, WX Yang - 2022 - digitum.um.es
… of male germ cells depends on spermatogenesis, which can … Loss function of OCT4 in mouse
showed the embryonic lethal… in the primordial germ cells led to germline cell death (Nichols …

The Death of Sperm Cells

KK Kavaldzhieva, DK Dimitrova-Dikanarova… - Acta Medica …, 2023 - sciendo.com
… The first prerequisite for sperm cells to be functional is, of course… the current state of
knowledge about male germ cell death. … During the first spermatogenic wave, apoptosis of large

[HTML][HTML] The molecular mechanism of sex hormones on Sertoli cell development and proliferation

W Shah, R Khan, B Shah, A Khan, S Dil… - Frontiers in …, 2021 - frontiersin.org
cells may facilitate the timely onset of the first spermatogenicnecessary to investigate its
actual function in postnatal testis … of spermatogenesis and increased germ cell apoptosis (108). …

[HTML][HTML] TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility

LA Torres-Fernández, J Emich, Y Port… - … and Developmental …, 2021 - frontiersin.org
… TRIM71 function is essential for embryogenesis and its … spermatogonia, also known as
spermatogonial stem cells (SSCs… nor signs of abnormal cell death upon regular media change, …

COP9 signalosome complex subunit 5, an IFT20 binding partner, is essential to maintain male germ cell survival and acrosome biogenesis

Q Huang, H Liu, J Zeng, W Li, S Zhang… - Biology of …, 2020 - academic.oup.com
… was present in cytoplasm of spermatocytes, the acrosome of … investigate its function in
male germ cells, we used germ cell-… in male germ cells, regulation of spermatocyte apoptosis, …